Proud to see that not one but two current postdocs in my lab are selected as finalists for the esteemed Life Sciences Research Foundation fellowship: Dr. Miao Liu (also my first PhD student) and Dr. Zifeng Wang. Congrats to you both! ⁦Yale Department of Genetics⁩ lsrf.org/finalists/

Today we celebrate the third PhD defense from the lab this year. Congratulations to our super star graduate student Yubao Cheng for receiving his well deserved Yale PhD!

a real pleasure to write this piece with Martin Pera and Patrick Tam, where we reflect on recent insights and open questions in early human development: doi.org/10.1242/dev.20…

Fresh off the press in Nature Methods In this highlight video, Siyuan (Steven) Wang and Yubao Cheng at Yale University unveil a powerful new platform to decode 3D genome architecture. Perturb-tracing IDs new regulators of chromatin organization at multiple length scales. youtu.be/oR63uI8feWs

Thank you TDCC @genometdcc.bsky.social for the wonderful video highlighting our newly published paper in Nature Methods introducing Perturb-tracing that enables high-content screening of multi-scale 3D genome regulators! Link to paper: rdcu.be/ehbid

Perturb-tracing integrates CRISPR screening with barcode readout and chromatin tracing for loss-of-function screens, facilitating the study of chromatin folding regulators. Siyuan (Steven) Wang Yale School of Medicine Yale University Yale Department of Genetics Yale Cell Biology nature.com/articles/s4159…

Congratulations to the newly minted Yale Doctor Yanbo Chen! Our final PhD defense this year (4 in total).

How does 6 feet of DNA fit inside a cell that's only 10 microns wide? 🤔 Siyuan (Steven) Wang presents a brief history of contemporary 3D #genomics techniques. Learn how spatial organization of DNA plays a vital role in gene regulation, development, and disease youtube.com/watch?v=gXCONU…

Just received my F31 score, and I'm in awe. So ecstatic the effort was noticed. Huge thanks to the team backing me up through this process, especially my PI Berna Sozen 🤍 Grateful to be part of Yale Department of Genetics #womenshealthresearch let’s gooo!!!

Check out this new video highlighting our lab :-) Thank you Yale School of Medicine Video Team for the production! m.youtube.com/watch?v=p-hEUt…

Excited to share our latest paper in Nature Genetics with Siyuan (Steven) Wang on the evolution of 3D genome organization in 🐁 models of #LungCancer and #PancreaticCancer. Kudos to Miao Liu Sherry Su! Yale Department of Genetics Yale Cancer Center Yale Cancer Biology Institute nature.com/articles/s4158…

Muzumdar Lab Nature Genetics Miao Liu Sherry Su Yale Department of Genetics Yale Cancer Center Yale Cancer Biology Institute Wonderful collaboration with you and your team Mandar!

Glad to share our latest publication in Nature Genetics Nature Genetics: Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. In this work, we generated the first single-cell 3D genome atlases of any cancer using any technique.

💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space. Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬. It’s the first 3D genome atlas of cancer progression. Thread 👇

Congratulations to Yale Genetics faculty Dr. Berna Sozen Berna Sozen and Dr. Steven Reilly Steve Reilly, who have been named 2025 Pew Biomedical Scholars! 🎊🧬🔬medicine.yale.edu/news-article/y… #PewBiomedicalScholars #Genetics

Thank you, Dr. Alfredo Rodríguez and the Fanconi Cancer Foundation, for inviting me to present as a keynote speaker! It’s so inspiring to learn about the tremendous progress by colleagues working on Fanconi Anemia that has drastically improved patient life expectancy.

Spatial Biology just leveled up! Siyuan (Steven) Wang introduces RAEFISH in this latest publication highlight Whole-transcriptome imaging at single-molecule resolution. See 20,000+ RNAs light up in cells and tissues. Plus direct gRNA detection for CRISPR screens youtube.com/watch?v=P2j6ax…

Our RAEFISH spatial transcriptomics technology is now published in Cell Cell! RAEFISH enables sequencing-free whole genome spatial transcriptomics at single molecule resolution. This work represents the first time that transcripts from more than 23,000 genes were

Excited to see my PhD work out! Here, we find an unexpected epigenetic mechanism that regulates oncogene amplification to promote tyrosine kinase inhibitor resistance in lung adenocarcinoma. Tweetorial below! ⬇️ nature.com/articles/s4159…

Glad to write this journal club piece for Nature Reviews Molecular Cell Biology. nature.com/articles/s4158… Here I review a fundamental discovery by Dunn et al. in 1984 that established the concepts of DNA looping and transcription regulation by 3D genome folding. I still recall my