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Excited to share our paper on ILC1 and NK cell ontogeny. Embryonic ILC1s persist and mature in the liver, forming cytotoxic effectors - postnatal wave brings first NK cells and more ILC1s. Now in Science Immunology science.org/doi/10.1126/sc…

Aloha! Ready for ILC4 2020 & ICIS 🦋 @cytokinesociety.bsky.social Looking forward to present our posters and listen to awesome science! #ILC4 #Cytokines2022 Colin Sparano Marijne Vermeer

Widely-used drug Azathioprine causes suprsingly selective loss of NK cells and Th1 impairment, with patients suffering from frequent herpes virus re-activations. Check out our paper: jacionline.org/article/S0091-…

Spectacular last sunset at Cytokines 2022 / ILC4 going down behind the next generation of cytokine biologists & innate lymphoid cell researchers who will be the ones turning what we know today into promising therapies when the sun comes up tomorrow. #cytokines2022 #ilc4

We are excited to share our recent paper with the title “Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory”, led by @TimoRckert, in which we study the origin and maintenance of human adaptive NK cells! nature.com/articles/s4159…

Interested in Tissue Homeostasis and Immunity? NK cells and ILCs? join this fantastic nk-symposium.org with lots of exciting science from Joseph Sun Lab, Eric Vivier, Maini Lab UCL, Mackay Lab, Björkström lab, Ari Molofsky, @Hepworth_Lab...

Looking forward to our next #globalimmuno talk this Wednesday, May 3rd at 9am PST, noon EST, 4pm GMT by Dr. Sonia Tugues. Title: “Ontogeny and anti-metastatic function of group 1 innate lymphocytes” LINK: ucsd.zoom.us/j/91053505061

Please ask questions for today's Global Immunotalk by Dr. Sonia Tugues HERE by replying to this tweet. Don't forget to mention #globalimmuno. Sonia will use the account TuguesLab to answer questions.

Enjoyed a wonderful meeting in Würzburg! Thank you for bringing together so many great people from the NK and ILC community Georg Gasteiger

Excited to share our work on Tregs in the TME at this fantastic conference #CICON23! @BecherLab TuguesLab Pascale Zwicky AACR ENCI Cancer Research Institute

Now out in Science Immunology! Our work on how metabolic stress of hepatocytes triggers inflammation in NASH. First clues for a non-invasive biomarker for the disease in humans science.org/doi/10.1126/sc…

B cell depleting therapies effectively treat #MultipleSclerosis, yet our understanding of why remains limited. How does loss of B cells impact the immune system in MS? See our multicohort study employing high-dimensional single-cell immunophenotyping: cell.com/cell-reports-m…

Thrilled to share our latest collaboration with @Becherlab: "IL-23 stabilizes effector Treg program in tumors" by Tobias Wertheimer and Pascale Zwicky et al. out now in Nature Immunology. Check out the great tweetorial of the @Becherlab !

Looking forward to visit Zurich next week🫶 Please come to give us some comments for our T cell exhaustion project which I am super excited about🫡

New position is open! Cerwenka and Tugues lab will work together on innate lymphocyte responses in metastatic melanoma and immunotherapy

I had a good time in Lyon at my first "NK&ILC Meeting"; great science, talks and people! Thanks to the German Society of Immunology (DGfI - dgfi.org) for having gathered all these amazing scientists from around the world. TuguesLab

Visit the Novel Concepts in #Innate_immunity #Conferences website to submit an abstract and see a list of confirmed speakers, e.g. Bruno Lemaitre, Luke O'Neill, Aude Bernheim, Clare Bryant ([email protected]), Veit Hornung, The Leibundgut lab, Lennon Lab, Lloyd Lab NHLI, Rosa Paolicelli, Sarris Lab, TuguesLab

Excited to share our new paper in Journal of Experimental Medicine 🎉 We show that NK cells use autocrine TGF-β1 signalling to establish tissue residency, form a highly cytotoxic subset, and protect the tissue against viral persistence. rupress.org/jem/article/22…

Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells, say Colin Sparano (Colin Sparano), Darío Solís-Sayago (Darío Solís-Sayago), Sonia Tugues TuguesLab and colleagues University of Zurich: hubs.la/Q0302VDw0 #InnateImmunity #LymphocyteBiology

Myers, Reilly, & Brossay Brown University discuss work by Colin Sparano, Darío Solís-Sayago et al. TuguesLab (hubs.la/Q03155TM0) which shows that tissue-resident NK cells produce TGF-β1 themselves to establish and maintain residency in glandular tissues. hubs.la/Q03157gF0