I thought AppleMusic showed some deep magic dealing out the Rave Ups “Positively Lost Me”, which I haven’t heard for decades but no it’s just because they are from Pittsburgh 😡

What does the RNA binding surface of PRC2 actually do?

We show that part of the RNA binding surface is required for PRC2 function through interactions with nucleosomes, but we find no evidence that RNA is in play.

nature.com/articles/s4158…

Extremely fascinating

Very surprised and excited to watch the Aurora Borealis from Cold Spring Harbor Laboratory and Bayville, Long Island, NY. With Sanchari Ghosh

You have to travel in time to stop me from eating a third Arby’s. Def Leppard’s Foolin is playing. What year do you have to set the time machine for

You put it all out there and gave us everything to enjoy, Roger. Thank you. What a legend.

It’s a fun movie that wants you to have fun. What…is this strange emotion

Trigger warning: Fall Guy extensively features one of the only tolerable KISS songs but it’s more tolerable when you forget it is KISS

Newsies (1992)

POINT BLANK (1967) Lee Marvin, Angie Dickinson, Keenan Wynn. Dir: John Boorman 2:45p ET (11:45a PT)

A betrayed thief seeks revenge on his former partner.

1h 32m | Crime

Did you miss the northern lights last night or early this morning? If so, you have a chance to see them tonight if the clouds don't interfere. The potential for a G5 tonight denoted by the dark red bars. #aurora

After a constructive set of reviews, our single-cell reporter work is OUT nature.com/articles/s4159…
Check out the briefing if you want the tldr nature.com/articles/s4159…
I am particularly fond of some of the new applications.
Mini-update.

I can't stop laughing

When Steve Albini died, we were getting ready to publish a career-spanning interview with him ahead of the new Shellac album. Here it is: stereogum.com/2262790/steve-…

Albini could say the dumbest things, but the broad outlines of his cultural philosophy were visionary. We live in a docile age of obedient consumerism and consensus-driven political and corporate tyranny. This isn't mandatory. Anger can be power. Did you know that you can use it?

JAM

In GQ: an excerpt from “The World Is Yours.” gq.com/story/oliver-s…

What are the functional roles of 3D genome organization? Our paper in nature led by Prashant Bhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. rdcu.be/dHkez