For all #BBB lovers and neurovascular fans, check out our new study that is out today in PNASNews 👇🏻 Prenatal disruption of blood–brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation pnas.org/doi/10.1073/pn…

Propagation of Lipotoxicity-induced #SkeletalMuscle #ERStress via #ExtracellularVesicle packing long-chain #Ceramide #MyoTwitter Dr. Lee Roberts lab Nature Communications 2022 @Roberts_Lab nature.com/articles/s4146…

Research| Paul Cheng et al. show that #SmoothMuscleCell-specific deletion of #Smad3 resulted in increased SMC-derived #chondromyocytes, increased outward remodeling and #plaque #calcification. Stanford Medicine| nature.com/articles/s4416… 👉rdcu.be/cLzOf

Microvascular stabilization via blood-brain barrier regulation prevents seizure activity | Nature Communications So much to unpack here 🧐 Check it out for all things #claudin5! #bloodbrainbarrier #Epilepsy doi.org/10.1038/s41467…

Endothelium protects #SmoothMuscleCell from H2O2-induced, caspase-/Ca2+-dependent Death in pressurized🐭#PosteriorCerebralArtery EC-derived cytoprotective factor for SMC? NOT #GapJunction #CarbonMonoxide #NitricOxide Dr Steven Segal lab Acta Physiol 2022 onlinelibrary.wiley.com/doi/10.1111/ap…

Trafficking in blood vessel development A nice review on #RabGTPase #VesicleTrafficking machinery in #EndothelialCell #Angiogenesis Sprouting Junctional dynamics Lumenogenesis VEGFR2/VE-cad/Notch/Integrin/WPB Dr. Erich Kushner lab Angiogenesis 2022 link.springer.com/article/10.100…

#EndothelialCell Notch KO <3 mo -> Artery #TertiaryLymphoidStructure🐭Kidney/Lung/liver Enthralling🤩Artery acquiring #HighEndothelialCell phenotype! Arterial mural cell phenotype? Origin of TLS FRC?😋 Dr. Florian Limbourg lab Nature Communications 2022 Susanne Fleig nature.com/articles/s4146…

🐭ACE2 expression spectrum Abundant ACE2 in #Pericyte (CNS/Heart/Pancreas...), SMC subsets but Not #EndothelialCell In Lung, ACE2 mainly detected in AT2 & multiciliated airway epithelium Dr Urban Lendahl & Christer Betsholtz labs StemCellReports 2022 sciencedirect.com/science/articl…

Translating the Force - mechano-sensing GPCRs A rich collection👇 AT1R PAR1 S1PR1 M3R FPR PTH1R B2R GPR68 H1R APJ +Adhesion GPCRs 🤠Crosstalks with mechanosensitive ion channels Dr. Ines Liebscher lab AJP-Cell Physiology 2022 @Caroline_Wilde2 @LiebscherLab journals.physiology.org/doi/abs/10.115…

Details matter A super-detailed protocol to stain & quantify 3D (150-μm slice)🐭brain vasculature Density Branching Tortuosity Learning a new trick, I will try fish gelatin in IHC next😆 Dr. Baptiste Lacoste lab Neurophotonics 2022 @BaptisteLacost3 spiedigitallibrary.org/journals/neuro…

An exquisite, quantitative map of🐟zonated #EndothelialCell morphodynamics🤠 Directional migration+Mitosis 26-38hpf #WallShearStress aISV vs vISV in situ vs in silico Dr. André Rosa & Holger Gerhardt lab Development 2022 André Rosa Holger Gerhardt journals.biologists.com/dev/article/14…

Cells of the #BloodBrainBarrier: An Overview of the Neurovascular Unit in Health & Disease Relearn BBB+#NeurovascularCoupling from this very enjoyable review by Dr. Heather McConnell Heather McConnell, PhD Dr. Anusha Mishra Anusha Mishra Methods Mol Biol 2022 link.springer.com/protocol/10.10…

#EndothelialCell #Mechanobiology #Mitophagy machinery (p62/PINK1/SMDT1) is required for #LaminarShearStress-activated MEKK2/3-MEK5-ERK5-KLF2 axis p62 #Autophagy adaptor physically scaffolds with MEK5 Dr. Brian Coon & Martin Schwartz labs Journal of Cell Biology 2022 rupress.org/jcb/article-st…

#CapillaryStalling caused by #EndothelialCell #Glycocalyx attrition #OpticalCoherenceTomography+2PM Heparinase+Hyaluronidase, or🐭#VascularDementia induced by Zoletil+xylazine i.p Mainly Leukocyte plugging Dr Wang-Yuhl Oh & Yong Jeong labs JCBFM 2022 journals.sagepub.com/doi/10.1177/02…

Monitor autophagic flux in mammalian cells easily with our new method, now out in eLife - the journal! Pulse-labeled HaloTag reporters are processed in lysosomes, releasing proteolysis-resistant labeled Halo. Free labeled Halo amount = autophagic flux! →western/in-gel fluo/microsc./flow cyto

A Review in Nat Rev Neurology provides detailed insight into how the gut microbiota influences the immune system and discusses the accumulating evidence that the gut microbiota is an important factor in multiple sclerosis pathogenesis. go.nature.com/3BQDcfU

OxLDL/LOX-1 Mediated Sex, Age, and Cell Dependent Alterations in Mouse Thoracic Aortic Vascular Reactivity biorxiv.org/cgi/content/sh… #biorxiv_physio

Final #ArticleinPress this week comes from UAZ Medicine - Phoenix. Ozanimod Differentially Preserves Human #Cerebrovascular #Endothelial Barrier Proteins and Attenuates MMP-9 Activity Following In Vitro Acute Ischemic #Injury (Trevor S. Wendt and Rayna J. Gonzales): ow.ly/JzVU50PNSf4

Arkelius et al found rats treated with #rt-PA after stroke, additional #LOX-1 and #MMP-9 inhibition reduced number & severity of #hemorrhages, & better maintained neurological function compared with rt-PA alone. Learn more at ahajournals.org/doi/10.1161/CI… Trevor S. Wendt

Thrilled to share this exciting work by Gonzales Lab and Trevor S. Wendt! UAZ Medicine - Phoenix UAZ Medicine - Phoenix TCRC BIO5 Institute