In Journal of Experimental Medicine, Tobias Deuse, Hu, Lanier, Schrepfer, Agbor- APO Lab (Applied Precision Omics) et al. report that disruption of the SIRPα-CD47 immune check point increases aggressiveness of NK cell-based immuno-oncology: bit.ly/2Xqt4Vm Dr. Agbor-Enoh Omics Lab @TheBethesdaLabs Hopkins Pulmonary and Critical Care Medicine #StemCells

Congrats to team on pnas proof of concept: Hypoimmune cells to treat dx in mice!Hypoimmune cells evade the host immune system, and engraft in fully allogeneic recipients without immunosuppression. pnas.org/content/118/28… PNASNews UCSF Surgery UC San Francisco ISSCR The ISHLT

Vote for Sonja! California Life Sciences Award-scientific advancement award Gladstone Institutes UCSF Heart & Vascular Care UCSF Surgery UCSF Howard C. Naffziger Surgical Society Surgical Innovations UCSF Health

Meet the finalists for the #Pantheon2021 SCIENTIFIC ADVANCEMENT AWARD: VOTE: bit.ly/3yXghKK •Daniel A. Erlanson, Ph.D. Frontier Medicines •Benjamin L. Oakes , Ph.D. •Sonja Schrepfer, M.D., Ph.D. Award Presented by CLS FAST #FosteringInnovation

Want a glimpse into the future of cell therapeutics? openaccessgovernment.org/the-future-of-…

How do Astronauts age in Space? Help UCSF Space A.G.E. researchers by designing a mission patch! US Middle/High School students, join the Mission Patch Contest. Submit by July 31: bit.ly/spaceagecontest Space A.G.E. Tobias Deuse UCSF Transplant @UCSpacehealth Aenor Sawyer

We have learned that antibodies jeopardize long-term graft survival in solid organ transplantation. That's why we have developed an engineering concept to protect cellular grafts from all cytotoxic IgG attacks. ISSCR UCSF Surgery UCSF Health

Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity dlvr.it/SyJq3D

Online Now! Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate dlvr.it/T2Tpqq #stemcells

Fresh off the press at NEJM! Hypoimmune (HIP) primary human islets survive and produce c-peptide in an allogeneic patient with diabetes. Without immunosuppression! Congratulations to Sonja Schrepfer and her Sana team and the Uppsala investigators! NEJM UCSF Surgery

Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report:

The success story of HIP continues! In 2019, we reported our hypoimmune (HIP) engineering that protects cells from allogeneic immune cells. What followed were multiple studies in mice and non-human primates supporting the robustness of HIP immune evasion. Now, 6 years later, the

Hypoimmune (HIP) CD19 CAR T cells escape allorejection in patients with cancer and autoimmune disease! cell.com/cell-stem-cell…

Online Now! Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease dlvr.it/TMT4JW #stemcells

Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease dlvr.it/TMtNFJ

Our latest issue is out! Highlights include reports on the immune response to allogeneic cell therapies in clinical trials with iPS-DA neurons and primary hypoimmune CAR-T cells, a PDAC organoid biobank that IDed use of statins in a clinical trial, & more! cell.com/issue/S1934-59…

Face off: Stem cell therapy versus the immune system dlvr.it/TMvZ8f