Mouse brain pre (L) & post clearing (R) + spatial mIHC - we'll be able to precisely map key tumor components: Samuel Widodo Marija Dinevska RaihanahP Keast Lab. Thanks for pioneering work - ClearT2 CLARITY iDISCO et al., especially work by Ali Max Erturk #GBM #braintumors UniMelb MDHS

Back at #lornecancer! Highlight was Michelle Monje🎗️ 's neuro-glioma talk! photo with fabulous researchers Samuel Widodo Marija Dinevska Miguel A. Berrocal Rubio checkout SW's poster #215 'Transcriptional reprogramming of tumour associated macrophages in glioblastoma'

Last day at Lorne Cancer Conference!

Tumor perivascular niche? In #glioblastoma the perivascular niche has collagen, lymphocytes, macrophages - all trapped infiltrating immune cells. Using spatial mIHC we investigate how #ECM & secreted factors regulate tumor immunity #GBM Doherty Institute UniMelb MDHS Akoya Biosciences

For today's #TissueTuesday, we're featuring high-plex #PhenoCyclerFusion images of the mouse brain. The first image presents a whole slide view of a mouse brain, showcasing the normal brain tissue and the presence of #Glioblastoma. The second image zooms in on the hippocampus

See our collaborative Akoya Biosciences UniMelb MDHS research @ #AACR2024 abs#3763 "Comparative spatial analyses of the tumor immune landscape in different brain cancer mouse models” - tinyurl.com/524s7pe2 #glioblastoma #GBM #Braincancer #cancer

Discover the intriguing differences in the tumor immune landscape across various mouse models of #glioblastoma! Join Fabrice at #AACR24, at Poster #3763, Section 44, Board 19, who'll share his insights until 5:00 PM today. Don't miss out on this opportunity to learn and engage!

Excited to finally see this work come out online Nature Portfolio. In this work we identify FOXO1 overexpression as a strategy to improve CAR T cell persistence and metabolic function using CAR T derived from mice, healthy donors and cancer patients. nature.com/articles/s4158…

Very pleased to announce our cooperative nature article with the Krönke lab about glucocorticoid effects in immune metabolism, thanks to Jean-Philipp, Max, Maria, Ulrich, Eicke, Jörg, Georg, Gerhard and many more excellent collaborators! Check out at nature.com/articles/s4158…

Excited to share our new paper in Cell on spatial organization in glioblastoma authors.elsevier.com/c/1izT9L7PXqQI9. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal five-layer organization of cellular states and a role of hypoxia as tissue organizer. 1/

Don't miss the Akoya Biosciences spatial biology session Doherty Institute on novel approaches investigating mechanisms in #Immunology #infection #BrainCancer & application of novel experimental & computational tools for #spatial in #organoids #pathology #cellsignalling #GBM UniMelb MDHS

Spatial Biology applications highlighting novel research, experimental models & computational tools investigating mechanisms in #Immunology #infection #cancer & application of novel #spatial #organoids #pathology #cellsignalling #GBM #Brain

This Wed May 22 at 3:30PM Doherty Institute, we'll highlight how we're using tissue spatial proteomics by Akoya Biosciences tech & other spatial tools to discover novel ways to boost anti-tumour immunity & kill brain cancer cells #GBM UniMelb MDHS bit.ly/4bl8Ssk #multiomic

Presenting our research at the WEHI Spatial Biology Symposium with talented scientists sharing a passion for the research nexus between biology & pathology #glioblastoma #brain #cancer #immunology Doherty Institute UniMelb MDHS

Congratulations to PhD student Philipp Graber on his first author review on ex vivo modeling of gliomas Childrens Cancer Institute UNSW Medicine & Health NanoMed buff.ly/3xfgHBo

Discover the future of 3D-omics! Our perspective aritcle explores how tissue clearing and AI with single-cell omics could revolutionize understanding of entire organs & organisms. Read the full article: nature.com/articles/s4159…

We share our review discussing several key studies investigating the immunosuppressive tumour microenvironment, with a focus on brain cancer​ doi.org/10.1016/j.immu… Marija Dinevska Theo Mantamadiotis @BrainCancerLab

"Reprogramming the brain tumour microenvironment to enhance anti-tumour immunity" - Looking forward to the opportunity to present our research #GBM #glioblastoma #brain #cancer #immunology #research UniMelb MDHS Doherty Institute