Why do we ignore brain state during stimulation? Jessica M Ross, PhD developed sensory entrained TMS (seTMS) - sync TMS to musical beats to time stimulation when circuits are most receptive. Could be a low-cost, scalable way to boost outcomes. More to come.

There's a strand of the MAHA philosophy that's motivated in no small part by a bias against medicine—which often comes close to an aversion to illness, itself. In this philosophy, sunlight and exercise are good because they help healthy people stay healthy. Supplements are good

It’s wild how much change is possible in this life. From relearning to talk post-TBI, to full blown heroin addiction, to a life beyond anything I could have imagined. Im very fortunate to not only be alive, but to have been selected to speak at 2025 TEDxBoulder!

Animal models for psychedelic drug action--my (hopefully) final thoughts and recommendations: open.substack.com/pub/zendudest/…

Excited to share our latest work is up on bioRxiv! Looking at capillary flow speed changes we show that psilocybin prolongs the neurovascular coupling response to a visual stimulus. 🍄🔬🧠🩸 Preprint: biorxiv.org/content/10.110…

New preprint from collaboration with SchafferNishimuraLab - 2p imaging of psilocybin's effects on neurovascular coupling 🔬 We found that psilocybin prolongs the neurovascular response, independent of neural activity. This affects how we should interpret fMRI BOLD studies of #psychedelics‼️

Another awesome push to caution interpretive power of fMRI while under acute intoxication of psychedelics! Big should out to Rick Zirkel Alex Kwan 關進晞 and SchafferNishimuraLab !!!

🎯 Algorithm Accuracy Award 🎯 Daniel Ryskamp Rijsketic, Austen Brooks Casey, and @theborislab (Stanford Medicine) created UNRAVEL, a Python library for whole-brain fluorescent label mapping: b-heifets.github.io/UNRAVEL/

Can psychedelics benefit mental health without the trip? Boris D Heifets is testing ketamine under anesthesia—and challenging assumptions about how these therapies work. Listen now on Up First from NPR: n.pr/4ogOorT

Check out our latest paper in Nature Neuroscience (rdcu.be/ey7yk). This was a great collaboration with some very surprising results! Seems a glutamate burst & proximate IEG expression might not be necessary for structural plasticity induced by 5-HT2A partial agonists.

My recent email to Jay Bhattacharya, MD, PhD Robert F. Kennedy Jr Please RT!

New preprint + thread 🧵 #Psychedelics induce the formation of new synapses, but where do they connect? Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks. biorxiv.org/content/10.110… 1/12

Nonhallucinogenic psychoplastogens have antidepressant-like effects and promote cortical neuroplasticity through the same biochemical pathway as classic psychedelics, but don't cause immediate glutamate burst or IEG activation Olson Lab Institute for Psychedelics and Neurotherapeutics nature.com/articles/s4159…

I still get chills Meet Mike *30+ years severe depression *first hospitalized @ 13y *20 meds *3 rounds of ECT *2 near-fatal suicide attempts Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE see paper, thread doi.org/10.31234/osf.i…

Meet one of the winners of our MapMySections challenge! Daniel Ryskamp Rijsketic, Austen Brooks Casey, and @theborislab developed UNRAVEL, a tool that precisely maps fluorescent labels across the mouse brain. Join us on 8/27 for a webinar and live demo: alleninstitute.org/events/mapmyse…

Dr. Max Feinstein visited Stanford's Dream Lab to explore Boris Heifets' research on anesthesia-induced dreams. By removing surgery from the equation, Heifets’ team studies how these brain states arise and how they might be harnessed for mental health. bit.ly/45Bu8IR

We're hiring a lab manager to help run operations here at Princeton! We're a dynamic and friendly group of scientists, excited to collaborate and build our research vision at the new Omenn-Darling Bioengineering Institute & Neuro Institute! Apply here: hhmi.wd1.myworkdayjobs.com/en-US/External…

"The failure of naltrexone to block these beneficial [antidepressant, reduced alcohol use] effects of ketamine challenges the hypothesis that the therapeutic effects of ketamine are mediated by opioid receptor stimulation." academic.oup.com/ijnp/advance-a… 1/2

🌌 What happens in the brain when we dream? Excited to share our paper in Nature Communications that will hopefully lead us closer to answering that question: rdcu.be/eAwni Huge thanks to William Wong, Rubén Herzog Amunátegui Nao Tsuchiya and the other lead authors for the massive effort 🙏🙏

Jim Hudspeth has died 💔 I am so sad. He was probably my favorite hearing researcher of all time. Absolute genius and also generous - he spent hours on the phone advising me on my career even tho we barely knew each other. May his memory be a blessing. ted.com/talks/jim_huds…