🚀 Introducing Nucleotide Transformer v3 (NTv3) Today, we are very excited to share our latest foundation model for biology - Nucleotide Transformer v3 (NTv3). NTv3 is InstaDeep new multi-species genomics foundation model, designed for 1 Mb, single-nucleotide-resolution

Now on bioRxiv: Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by Filip Nemcko & Kevin Sabath in collab. with Plaschka Lab (IMP) biorxiv.org/content/10.648… (1/2)

I have always been fascinated by transcriptional activators that display intrinsic specificity towards some but not other promoter types as these imply alternative mechanisms! Hcfc1 directly bridges TFs to TFIID to overcome a rate-limiting step and activate CGI transcription.