Talk about a tour de force, Sam Young Jr.'s lab samyounglab has combined virology and neuroscience to challenge conventional wisdom on presynaptic Ca2+ channel regulation in this must-read paper. Congrats Sam! 🍾 Keep listening to the calyx of Held! 👂🧠 sciencedirect.com/science/articl…

Following in the steps of our mentors Dr. Harold Atwood & Dr. Milton Charlton to solve the mystery of synaptic heterogeneity, see our new story in Nature Communications : rdcu.be/bniFN #Nanodomainologists #SeeItPatchIt #SickKidsVsSynapticHeterogeneity

Another successful collaboration with our colleague Dr. Julie Forman-Kay moves us closer to understanding activity-dep translation of silenced mRNA. Check out our new paper in PNASNews on reversible mRNA granule formation by FMRP bit.ly/2Iz6ipS 🔬🧠 #SickKidsVsFragileX

RIP to my friend, mentor, and collaborator Professor Jim Howe of Yale School of Medicine Pharmacology. Here we are sharing a laugh with Jim’s former student Stacy Irizarry. Neuroscience has just lost one of the great electrophysiologists of our generation but we will never forget Jim’s laugh!

😍 #Want

#ThrowbackThursday to 4 yrs ago, when I first began the important mandate I received from our PM Justin Trudeau: to return science & research to their rightful place, after a decade of cuts & muzzling of scientists by the previous govt. Today, our decisions are based on evidence.

Was a pleasure to co-supervise Ke Lai (future post-doc of the Wang Lab) on this project. In our collaboration with Shanghai Jiao Tong University, we have uncovered ASIC channels as a target in treating Neonatal Jaundice. Check out our paper in Science Translational Medicine stm.sciencemag.org/content/12/530…

awesome program

Pleased to share our paper in Neuron showing how Bilirubin acts as an agonist for TRPM2 and aggravates brain injury in stroke.| Home authors.elsevier.com/sd/article/S08…

Thrilled to be sharing the news of our latest grant award to samyounglab University of Iowa Carver College of Medicine, signifying a crucial first step in the development of a future #GeneTherapy for #CACNA1A-related disorders. Check out his conversation with @PangkongFox here: youtube.com/watch?v=u3bBuW…

Many congrats to Amy Yang for her new paper on the role of cerebellum in social recognition memory in Nature Communication published online: nature.com/articles/s4146…. So proud of my former trainees for their outstanding work and achievements.

CACNA1A Foundation UPenn Million Dollar Bike Ride by ODC The Orphan Disease Center @ UPenn We are humbled to receive this award. We thank the MDBR and CACNA1A foundation for supporting our research.

Check it out: most beautiful images of vATPase with a surprising partner on live synaptic vesicles from my brilliant colleague John Rubinstein and his team at SickKids Reaearch Institute & University of Toronto! science.org/doi/10.1126/sc…

A newly developed molecule could inform future therapies for stroke-related brain injury, finds #SKResearch in nature. Read ➡️ bit.ly/45Wh80h

This novel glutamate binding cavity can be exploited for development of stroke drugs, as exemplified by a new compound LK2 described in our paper.

Very proud to share our latest work in collaboration with Amy Yang, Mike Salter, Sean Egan on Intersectin 1 as a pivotal molecule for controlling the emergence of calcium dependent replenishment of the readily releasable pool in developing central synapses.

physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

I am so excited to announce that 2025 Pre-SFN “Giant Synapse Symposium” will take place at UCSD on Nov 14. Please join us for an exciting meeting with the latest breakthroughs in synaptic neurobiology. Registration is free but required for logistics. web.cvent.com/event/fac89654…