Dr Amol Akhade (@suyogcancer) 's Twitter Profile
Dr Amol Akhade

@suyogcancer

Oncology care , to give or not to give chemo , data analysis , oncology pharamocovigilance , enthusiastic critic, twitts are not twists

ID: 1135941148378247168

linkhttp://suyogcancerclincs.com calendar_today04-06-2019 16:07:29

6,6K Tweet

3,3K Followers

125 Following

Dr Amol Akhade (@suyogcancer) 's Twitter Profile Photo

Belzutifan vs Everolimus for advanced RCC second line post IO plus TKI. Inspite of exactly same median pfs ( 5.6 months in both arms ) and curves crossing each other) at second interim analysis at 18 months, PFS curves are well separated ( unequal censoring ??) and p value

Belzutifan vs Everolimus for advanced RCC second line post IO plus TKI. 

Inspite of exactly  same median pfs ( 5.6 months in both arms ) and curves  crossing each other) at second interim analysis at 18 months,   PFS curves are well separated ( unequal censoring  ??) and p value
Dr Amol Akhade (@suyogcancer) 's Twitter Profile Photo

Does covid-19 still has same impact in your country as it was during 2020-21 ? Do u think covid-19 is something to worry of beyond usual viral fever with cough and cold ? Does this vaccine still needs emergency use authorisation? My answer - NO for all 3 Vinay Prasad MD MPH

Dr Amol Akhade (@suyogcancer) 's Twitter Profile Photo

Lung cancer vaccine phase 2 trial has started in various countries and it is making news headlines . This is Lu-Ca-Merit -1 trial and name of vaccine is BNT-116 - It is IV mRNA Vaccine and it will be studied in combination with cemiplimab and Chemotherapy in various cohorts

Lung cancer vaccine phase 2 trial has started in various countries and it is making news headlines . 
This is Lu-Ca-Merit -1 trial and name of vaccine is 
BNT-116 - 
It is  IV mRNA Vaccine and it  will be studied in combination with cemiplimab and Chemotherapy in various cohorts
Dr Amol Akhade (@suyogcancer) 's Twitter Profile Photo

Tissue agnostic approvals from 2017 till now ESMO - Eur. Oncology . Lets see the Other side of the coin. 1 - It is great to have Tissue Agnostic approvals and works well for NTRK fusion, B-RAF mutation and RET fusion and to some extent for MSI high . But for HER2-3 plus and TMB high

Tissue agnostic approvals from 2017 till now <a href="/myESMO/">ESMO - Eur. Oncology</a>  .
Lets see the  Other  side  of the coin.
 1 -  It is great to have Tissue Agnostic approvals and works well for NTRK fusion, B-RAF mutation and RET fusion and to some extent for MSI high .

But for HER2-3 plus and TMB high
Dr Amol Akhade (@suyogcancer) 's Twitter Profile Photo

Esmo presidential sessions ESMO - Eur. Oncology #ESMO24 What is the exciting data to look forward to - My Take 1 - OS data for Keynote- 522 - pembrolizumab for Neoadjuvant TNBC. 2- NIAGARA - neoadjuvant Durvalumab plus chemo followed by sx and adjuvant Durvalumab for MIBC . 3 - OS data

Esmo presidential sessions <a href="/myESMO/">ESMO - Eur. Oncology</a> #ESMO24 
What is the exciting data to look forward to - 
My Take 
1 - OS data for Keynote- 522 - pembrolizumab for Neoadjuvant TNBC.  
2- NIAGARA - neoadjuvant Durvalumab plus chemo followed by sx and adjuvant Durvalumab for MIBC . 
3 - OS data
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oncologynewscentral.com/article/fda-opโ€ฆ Hello everyone, Do read my Opinon piece published on oncology news central Oncology News Central, about recent USFDA approval of blood based colon cancer screening test . Do give your feedback and opinions ๐Ÿ™‚ LARVOL Cancer Data etc OncoAlert FDA Oncology

Oncology News Central (@oncnewscentral) 's Twitter Profile Photo

New blood test for #colorectal cancer approved by FDA raises concerns with only 13.2% sensitivity for precancerous lesions. What does this mean for oncologists about the certainty of a negative test? bit.ly/4g0W2lY #CRC Dr Amol Akhade NEJM

Dr Amol Akhade (@suyogcancer) 's Twitter Profile Photo

Whats new data coming up at ESMO - Eur. Oncology #esmo24 in lung cancer ? What's coming up for Lung Cancer In ESMO 24 ? My Take Phase 3 data - 1- adjuvant durvalumab alone in completely resected NSCLC 2- second interim OS from Mariposa-2 trial 3 - low dose vs standard dose

Whats new data coming up at <a href="/myESMO/">ESMO - Eur. Oncology</a> #esmo24 in lung cancer ?  What's coming up for Lung Cancer In ESMO 24 ? My Take  
Phase 3 data -

1- adjuvant durvalumab alone in completely resected NSCLC 

2- second interim OS from Mariposa-2 trial 

3 - low dose vs standard dose
OncoDaily (@oncodaily) 's Twitter Profile Photo

Dr.Dr Amol Akhade about FDA Oncology approval of blood based colon cancer screening test Oncology News Central oncodaily.com/blog/132619 #Cancer #BloodCancer #OncEd #CancerScreening #OncoDaily #Oncology

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What's the new ADC data coming up from ESMO 24 ? Puxitatug samrotecan ( anti -B7-H4 ADC ) probably looks most promising . Rinatabart Sesutecan already has FDA fast track Designation ( FR-alpha ADC ) New Cludin6 and Claudin 18.2 ADC, Anti Her2 ADC and Trop 2 ADC data needs to

What's the new ADC data coming up from ESMO 24 ? 
Puxitatug samrotecan ( anti -B7-H4  ADC )  probably looks most promising .
Rinatabart Sesutecan already has FDA fast track Designation ( FR-alpha ADC ) 
New Cludin6 and Claudin 18.2 ADC, Anti Her2 ADC and Trop 2 ADC data needs to
Dr Amol Akhade (@suyogcancer) 's Twitter Profile Photo

What's new data coming up in PD-L1 negative advanced NSCLC? Volrustomig , monoclonal bispecific antibody in combination with chemotherapy for First line mNSCLC shows good ORR and DCR in phase 1b trial in both non Squamous and Squamous histology. But 7 treatment related deaths ,

What's new data coming up in PD-L1 negative advanced NSCLC? 
Volrustomig , monoclonal bispecific antibody in combination with chemotherapy for First line mNSCLC shows good ORR and DCR in phase 1b trial in both non Squamous and Squamous histology.  But 7 treatment related deaths ,
Dr Amol Akhade (@suyogcancer) 's Twitter Profile Photo

Doxorubicin plus Trabectedin followed by Trabectedin maintenance for leiomyosarcoma shows OS benifit vs doxorubicin alone . Median OS Improved from 24 months to 33 months NEJM See the post progression therapy for both arms ( 36 % of control arm got Trabectedin on

Doxorubicin plus Trabectedin followed by Trabectedin maintenance   for leiomyosarcoma shows OS benifit vs doxorubicin alone . 

Median OS Improved from 24 months to 33 months  <a href="/NEJM/">NEJM</a> 

See the post progression therapy for both arms ( 36 % of control arm got Trabectedin on
Dr Amol Akhade (@suyogcancer) 's Twitter Profile Photo

Ivonescimab vs Pembrolizumab. For First line NSCLC. Harmoni-2 trial. Remember PFS is already declared postive as clinically meaningful. In both Squamous and Non Squamous histology and in both PDL1 low and high subsets . Full data on this Sunday at #WCLC24 This is going to be

Ivonescimab vs Pembrolizumab.  For First line NSCLC.  
Harmoni-2 trial. 
Remember PFS is already declared postive as clinically meaningful. 
In both Squamous and Non Squamous histology and in both PDL1 low and high subsets .
Full data on this Sunday at #WCLC24
This is going to be
David J. Benjamin, MD (@davidbenjaminmd) 's Twitter Profile Photo

In Clinical Oncology, Dr Mark Lythgoe and I comment on the state of supportive care in oncology. Metrics including drug approvals, global funding, and the number of ongoing clinical trials show a predominant focus on anti-cancer therapeutics over supportive care interventions.

In <a href="/ClinOncology/">Clinical Oncology</a>, <a href="/DrMarkLythgoe/">Dr Mark Lythgoe</a> and I comment on the state of supportive care in oncology.

Metrics including drug approvals, global funding, and the number of ongoing clinical trials show a predominant focus on anti-cancer therapeutics over supportive care interventions.
KOL Pulse AI (@kolpulseai) 's Twitter Profile Photo

Dr Amol Akhade Interesting blog on the HARMONI-2 backstory ๐Ÿ‘‰The Wild West of World Lung Cancer #WCLC24 kolpulse.com/uptempo-blog/tโ€ฆ