In a meta-analysis of 6715 pts w/ #CD, Dr. Laffin University of Alberta Surgery Department demonstrates, NOD2 risk-allele is associated w/ post-op recurrence in #CD w/ OR 1.64. This study examined all known genetic loci 154 linked to postop recurrence of CD @sivashivi bit.ly/38LMQko

Excited to see our UK-wide collaborative paper on #transition services in #IBD published in JPGN Huge thanks to Mark Beattie Rafeeq @DrJennyEpstein and many others BSPGHAN journals.lww.com/jpgn/Abstract/…

Delighted to present our #IBD work NIHR Southampton BRC seminar with Imogen Stafford and Guo Cheng on behalf of Mark Beattie and Sarah Ennis Thanks to all those who have contributed and supported University Hospital Southampton 💙 Southampton Medicine, especially all the patients #MachineLearning #personalisedmedicine

Our fantastic nurse specialists Rachel Russell and Jo H are completing the Jurassic coast challenge and raising money for Crohn's & Colitis UK this weekend If you can spare any money -> justgiving.com/team/IBDnurses…

Nutritional assessment in #IBD but what is the role of bioelectrical impedance? > In stable patients it does not identify active disease or poor nutrition > Must be aware of overweight individuals = common Thanks to ESPEN Mark Beattie Southampton Children's Hospital authors.elsevier.com/c/1dLId8Yy14~u…

We're looking for patient + public involvement in shaping personalised medicine research in #IBD -What are your priorities for the future of IBD treatment? -What should the focus be? -Do you want to steer the direction of our research? Get in touch Southampton Paediatric IBD with suggestions

Get in touch with your thoughts and priorities, what would make research more appealing and how we can make involvement a positive experience Looking for patients/families willing to steer our research strategy over the next 2-5 years. Get in touch Southampton Paediatric IBD Southampton Children's Hospital

#ArtificialIntelligence + #MachineLearning + #IBD practicalities + future prospects ->Evidence to date ->What about patient benefit? ->Genomics/Endoscopy/Precision Medicine Wonderful collaboration Johanne Brooks BSG Seb Frontline Gastro fg.bmj.com/content/early/…

Delighted to see this published IBDJournal & CC360, merging WES + RNAseq -> impact of variants in multiple genes Deleterious variation in the NOD-pathway reduces NFKB-transcription and upregulates alternative inflammatory transcripts in Pediatric #IBD academic.oup.com/ibdjournal/adv…

Great to be part of this important work Mark Beattie James Ashton Southampton Paediatric IBD Southampton Children's Hospital University Hospital Southampton 💙 University of Southampton #IBD

Deleterious Genetic Variation Across the NOD Signaling Pathway Is Associated With Reduced NFKB... in Pediatric Inflammatory Bowel Disease academic.oup.com/ibdjournal/adv… #bioinformatics #itrtg #mednews #rstats #IBD #crohns #colitis

Some thought-provoking insights and I really appreciate papers that put 🧩 pieces together and tell a story 💭Hypoimmune / altered inflammatory pathways involved in bacterial clearance and autophagy not new ideas but 🔑 to unpack and get to a ⤵️ 💡“precise molecular diagnosis”

Great to be part of this important work with James Ashton and Sarah Ennis Mark Beattie James Ashton Southampton Paediatric IBD Southampton Children's Hospital University Hospital Southampton 💙 University of Southampton #IBD

Headlines >Variation in NOD2-related genes = hypoimmune transcription in NOD-pathway >Contribution of common + rare variation >Method to cluster patients by molecular subtype >NOD2 = key for Crohn's disease, more than the 3 commonly associated variants Open access IBDJournal & CC360

On #WorldIBDDay2022 I would like to thank all of our patients, families + staff for contributing to 10+ years of #paediatric #IBD research There are more patients every year but there are more treatments, and we are closer to personalising management -> Mark Beattie Southampton Paediatric IBD

NOD2 in #crohnsdisease - we know everything right? Wrong! It's unfinished business -> Translational potential -> Role for rare variation -> Really a #monogenic cause of disease? Read our article in JCC Mark Beattie Ellie Seaby Southampton Children's Hospital Southampton Medicine academic.oup.com/ecco-jcc/advan…

A fantastic paper on the role of NOD2 in the pathogenesis of ileal Crohn’s disease and the inflammasome. Enjoyed reading this on a sunny Saturday morning. Thank you. 👇

Prediction of Crohn’s Disease Stricturing Phenotype Using a NOD2-derived Genomic Biomarker IBDJournal & CC360 NOD2 = risk stratifies patients at diagnosis -> #Personalisedmedicine based on stricturing risk Mark Beattie Ellie Seaby Southampton Children's Hospital Southampton Medicine academic.oup.com/ibdjournal/adv…

Really excited to see this in print. The first of (hopefully many) uses of genomics to predict outcomes in #IBD Translational science funded by @ESPR_EBN

From association to prediction: NOD2 as a genomic biomarker to predict high-risk stricturing #crohns academic.oup.com/ibdjournal/adv…