100th Anniversary #Viewpoint: G protein–coupled receptors: from radioligand binding to cellular signaling: buff.ly/4bXDmRV robert j lefkowitz Howard Rockman Duke University School of Medicine

March 2024 issue of Trends in Neurosciences: cell.com/issue/S0166-22… Free featured articles & more: cell.com/trends/neurosc… On the cover: ‘Tuning neural circuits and behaviors by microglia in the adult brain’, by Shunyi Zhao, Tony Umpierre & Wu Lab at UTHealth cell.com/trends/neurosc…

Thanks Trends in Neurosciences for featuring our review on the cover! Please give our paper a read if you are interested in how microglia tune neuron networks in adult brain! Microglia (blue) are on fire (red, neuron and apical dendrites)🔥 Thanks Wu Lab at UTHealth Tony Umpierre for your support!

Astrocyte Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice: Neuron cell.com/neuron/fulltex… Congrats to Joselyn, Chiran and the whole team on this one!

Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye! The dye is tartrazine, used in Doritos! science.org/doi/10.1126/sc…

Wu lab are presenting Society for Neuroscience (SfN)! We have 3 posters on microglia. Please come to talk with Manling Xie Jiaying Zheng (Fiona) 郑嘉颖 Shunyi Zhao and Jordy. Look forward to meeting you there! #sfn2024

Such a pleasure to host Lingxiao Lingxiao Wang 王凌霄 PhD defense today Mayo Clinic Graduate School of Biomedical Sciences. Appreciate his leading efforts in our lab to study microglia and macrophage function in brain injury. Very proud to witness him to mature as a talented and outstanding scientist! Many congrats, Dr Wang!

After some outage due to hosting moves, the single cell studies database Google Sheet frontend is back: nxn.se/single-cell-st…

Do you need an intro to analyzing (prote)omics data? This series of lectures may be helpful. We aimed to make them short & accessible. Enjoy watching & learning! youtube.com/playlist?list=…

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time

“Why Facts Don't Work”—my talk at Winter Brain. Thanks to Joyce Woo for organizing “Synaptic Control of Mesolimbic DA” & co-presenters Tom Hnasko, Abigail Elerding, Miguel Lujan, Thomas Jhou. Sorry I missed it (thanks United!) but silver lining—the video: youtu.be/vZAZ6uCkkWI

For readers interested in new epilepsy therapies in development, here's a comprehensive recent review nature.com/articles/s4157… rdcu.be/eaxv6

A cross-disciplinary conference dedicated to the cell surface Janelia Conferences HHMI | Janelia to connect tool developers and biologists from diverse biology fields. Application deadline: May 20, 2025. (Bonus: golden season of the Shenandoah NP nearby!) Xin Zhou Lab Xinbo Yang

The program is now finalized for the 2nd annual Hans J. Müller-Eberhard Symposium on Neuroimmunology and Glial Biology! The event will be held CNG at UTHealth Houston at Institute of Molecular Medicine McGovern Med School UTHealth Houston. Thanks all committed speakers and sponsors! Stay tuned!

Three-photon microscopy: an emerging technique for deep intravital brain imaging | Nature Reviews Neuroscience nature.com/articles/s4158…

We are proud to share our latest study published in Science. After achieving efficient and clinical feasible microglia replacement for the first time in 2020 (PMID: 32783928), we applied this strategy to treat a severe and fatal neurological disease, ALSP, and observed remarkable