Our review on the inoculum effect of beta-lactams is out!

Metformin induced a greater reduction in SARS-CoV-2 viral load than placebo in the COVID-OUT study -- now in Clinical Infectious Diseases. Carolyn T. Bramante, MD, MPH David Boulware, MD MPH doi.org/10.1093/cid/ci…
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Lemons are a human invention.

The same is true of:-

→ Grapefruit.
→ Oranges.
→ Limes.

You would never find them in the wild.

They were created by selectively breeding from three primary ancestors native to South and East Asia.

→ Citrus.
→ Pomelos.
→ Mandarins.

When…

Do bakers daydream about leaving their job to do a PhD in molecular biology?

Antidiabetic agents with dose adjustments for renal function

H/t pharmahub #MedEd #MedX #pharmacology

King 👑

Enterobacter cloacae after a dose of a ceftriaxone

One Pearl to Rule them All. One Pearl to Find them. Check out this week’s KASIC pearl where we band together many of our stewardship pearls in Beat the Bug: Pseudomonas aeruginosa ➡️tinyurl.com/3nweewee

Kentucky Department for Public Health Kentucky Infection Prevention Training Center Kentucky Antibiotic Awareness KY Hospital Assoc KAHCF/KCAL…

Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies

doi.org/10.1021/acsinf…

Wait I am happier with this one.

Cryptococcus accounts for up to 180,000 deaths annually and 68% of HIV-related meningitis cases. The authors of a new review discuss diagnostic, preventive, and therapeutic strategies and the pathophysiological role of inflammatory syndromes. Full review: nej.md/44ni39a

Severe cutaneous adverse reactions (SCARs) are life-threatening conditions.
Genetic predisposition, impaired drug metabolism, viral reactivation or infections, and heterologous immunity influence SCAR development and presentation.
go.nature.com/3UwZJHe

👻

Happy May! 🌼
Incase April was super busy for you, we put together a summary of interesting articles for you to check out. If you have any extra, please let us know in the comments!

Not great news!! Transcontinental Dissemination of Enterobacterales Harboring blaNDM-1 in Retail Frozen Shrimp | Foodborne Pathogens and Disease liebertpub.com/doi/abs/10.108…

The search for authentic microbiome–disease relationships.
A new study challenges the validity of previously reported microbial markers and serves as a wake-up call for the #microbiome research field. News and Views from Ruixin Zhu & colleagues
nature.com/articles/s4159…

Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance

rdcu.be/dGoKd

Shepherd, Brockhurst & co. explore clinical evidence for ecological & evolutionary mechanisms of within-patient antimicrobial resistance emergence.

Clindamycin be like 🥲

Top 5 advantages that PhDs have outside of academia (save these for your next interview):

1. We know how to teach ourselves.

Every PhD has a story (or five) of how they had to learn a new topic in a few days. We know how to teach ourselves with minimal supervision - we were…

Multiple pattern recognition receptors are involved in recognition and immune response modulation, each responsible for a Candida molecule. go.nature.com/494K3Pq