🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in Science Advances . Equal-first co-authors Chris Lupton & Laura. Work lead by @Dr_Ellisdon. Funding from Department of Defense 🇺🇸 & Australian Research Council. science.org/doi/10.1126/sc…

I’m thrilled to share this story from Joshua Mendell and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation. science.org/doi/10.1126/sc…

HHMI Investigator Joshua Mendell (Joshua Mendell) at UT Southwestern Medical Center helped discover that tRNAs play a role in stabilizing or degrading some mRNAs during translation. Their findings could one day help tailor vaccines and disease therapies. Learn more: hhmi.news/4hZMqJa 👈

Our experience with #alphafold3 🤖 (code recently released) and some of our most recent #cryoEM 🔬 structures (thread below) nature.com/articles/s4158… nature.com/articles/s4146…

We performed subtomogram averaging on complexes from >3 MDa to ~200 kDa, including 80S ribosomes, Rubisco, clathrin, microtubules, ATP synthase photosystem II, and nucleosomes. Most density maps achieved sub-nanometer resolution!🔬✨ #CryoET #StructuralBiology #VisualProteomics

Hi, it’s nice to meet you. I am a #brain scientist. My life's mission is to prevent #Alzheimer’s disease and related dementias...or to contribute enough puzzle pieces so that someone else can unlock the mysteries of disease. I might take a day off, but if I’m being honest, maybe

Interesting in learning to process cryo-ET data in the latest version of Warp? I'll be running a workshop on April 22nd in central London, UK details+registration: forms.gle/u4Hk73jhenMvpN… Hope to see you there!

The self driving multi-scale microscope from Stephan Daetwyler is out. It can image a whole zebrafish embryo longitudinally and follow a region of interest with high resolution. We use it to study immune-cancer cell interactions. nature.com/articles/s4159…

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" biorxiv.org/content/10.110… We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during vesicle fusion ❄️🔬⏱️

"Don't be afraid!" Randy Schekman says that the most successful scientists are willing to take risks. He uses 2024 chemistry laureate David Baker as an example of how embracing risk can lead to significant rewards. Before Baker transitioned to researching structural biology he

Last night my brilliant friend with 20 years of expertise in Neuroscience including a decade at NIDA was fired because she was recently promoted for her outstanding performance and it triggered the probation period. This is not making NIH more efficient, this is not making us

Our manuscript for remote focus stabilization for oblique plane microcopy is online: opg.optica.org/boe/fulltext.c…

1/8 Cryogenic electron tomography (cryoET) is a revolution already in motion! Misha Kudryashev 🔬 ❄🕊️ argues that in situ structural biology is exploding, forcing us to rethink cells, molecules, and collaborations: tinyurl.com/4x4bf9ze Let’s unpack that 👇 #CryoET #StructuralBiology

We have a preprint for you EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer By Elena Vazquez-Sarandeses, Vasya Vasilii Mikirtumov Jeff Noel&Oli Daumke biorxiv.org/content/10.110…

Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ... Fan Liu lab and team show how cross-linking MS can be used to build novel models of unknown complexes, like a giant virus❄️ ❄️biorxiv.org/content/10.110…

A UT undergrad wrote a very interesting paper that uses neural cellular automata to solve some of the Abstraction and Reasoning Corpus (ARC) AGI benchmark problems. NaturalSciences @ UT arxiv.org/abs/2506.15746

The next discovery in treating brain diseases may come from tiny cell structures. David Sanders, Ph.D., studies biomolecular condensates and their role in Alzheimer’s/ALS—work that earned him the NIH Director’s New Innovator Award. Explore more: bit.ly/4o8rsKe #UTSWMed

Returning to Science Twitter briefly to thank the UTSW newsroom for their kind story on my New Innovator award. Humbling experience. A few thank yous to follow, as most haven't switched to the "other" place. :)

Diamond Lab at UT Southwestern for recruiting me to this wonderful institution; brangwynnelab for taking a chance on a postdoc with a psychology degree; Sarah H. Shahmoradian for co-leading our remarkable group of scientists; and our amazing lab members and NIH for believing in our high risk research!