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Interpreting non-coding disease-associated human variants using single-cell epigenomics go.nature.com/3BsYVcp #Review by Kyle Gaulton, Sebastian Preissl & Bing Ren UC San Diego School of Medicine Universität Freiburg Center for Epigenomics @ UC San Diego UC San Diego Ludwig Cancer

Open PhD position! If you are interested in analyzing the spatial dynamics of heart failure pathogenesis through integrative analysis of single cell transcriptomes, epigenomes and subcellular spatial transcriptomes, check here how to apply! meinbio.uni-freiburg.de/bilder/ausschr…

Out today Nature Genetics our work on mechanisms of beta cell dysfunctions in type 2 diabetes (T2D) combining single-cell genomics and Patch-seq. Congratulations to gaowei wang Josh Chiou, Chun Zeng. Big thanks to Kyle Gaulton Sebastian Preissl XX, F Kandeel, S Kim. rdcu.be/dcZQs

Robust enhancer-gene regulation identified by single-cell transcriptomes and epigenomes dlvr.it/Sqvk60

Do you enjoy the study of gene regulation and the outdoors? Come join our international team in sunny Freiburg, Germany! #phdposition #generegulation #spatial #singlecell #epigenetics #heart jobrxiv.org/job/preissl-la…

Our August 2023 issue is now live! In this Focus issue (go.nature.com/3pYr3Sf) and its accompanying collection (go.nature.com/3Q59gn9), which includes older reviews, we highlight the exciting developments in single-cell omics and their transformative potential

🍺I am so excited that my first paper is online (nature.com/articles/s4159…)! Joint profiling of histone modifications and transcriptome are critical to understand the active or repressive gene regulatory network. We therefore develop Droplet Paired-Tag,

Ancient question with a new twist! Check our new study by Schüle, Weckerle et al. authors.elsevier.com/c/1hekh5Sx5gtx… showing how TBX TFs Eomes&Brachyury specify cell lineages during gastrulation in a sequence. Eomes first dominates over Brachyury which only acts once Eomes left the scene.

In 21 papers across Science, Science Advances, and Science Translational Medicine, researchers with the #BICCN consortium present an atlas of the human and nonhuman primate brain in unprecedented detail. The results uncover the genetic organization of the human brain. scim.ag/4ro

So excited that our work is published in Science today! 📣We profiled regulatory elements from 1.1 million cells across 42 distinct human brain regions🧠, and associated relevant cell types to 19 common neuropsychiatric disorders. Science Magazine #BICCN doi.org/10.1126/scienc…

📅 Save the date! Don’t miss the 3rd Symposium on Medical Epigenetics by CRC992 MEDEP. 18-20 March 2024 in #Freiburg (Germany) Registration is already open: sfb992.uni-freiburg.de/symposium2024/

Age-related structural and functional changes of the intracardiac nervous system biorxiv.org/cgi/content/sh… #bioRxiv

This week in Nature: Brain maps - High-resolution cell atlas of entire mouse brain offers genomic, epigenetic and anatomical insights Browse the full issue: nature.com/nature/volumes…

Nature research paper: Single-cell analysis of chromatin accessibility in the adult mouse brain go.nature.com/3tlArRC

Laurette et al found an efficient #AAV-based method for #CRISPRi-mediated epigenetic silencing of gene expression in cardiac myocytes in vivo and in vitro. Learn more at ahajrnls.org/3vQkYKl @Patrick_Irt @Ralf_Gilbach Eileen Furlong Lisa Weiß

Beautiful cover image for February, courtesy of authors Universität Freiburg, shows whole mount image of the pacemaker cells, M2R, and glycocalyx of the cell membrane of a mouse sino-atrial-node. See their full article: buff.ly/3SND4pq Eliza Sassu Sebastian Preissl @CallumZgierski SFB1425_MakeBetterScars

Ob Genomanalyse von Tierarten oder des Coronavirus – der in Freiburg beheimatete europäische #GalaxyServer ist ein wichtiges Werkzeug für datenintensive Forschung. Bioinformatiker Björn Grüning erklärt, warum. badische-zeitung.de/wir-nennen-es-… Björn Grüning Galaxy Project #galaxyproject

Our #spatial #filtering #tool might be useful for a broader audience to dissect #mechanics #patterns in #AFM force maps nature.com/articles/s4159… CIBSS Universität Freiburg NatRevMaterials

Nature research paper: Spatially organized cellular communities form the developing human heart go.nature.com/48Tw92N

❓What is the course of 🫀 remodeling and recovery during and after prolonged catecholamine treatment? 🐭 assigned to 14 days soprenaline+phenylephrine 🧬⬆️LV contractility/🫀fibrosis+hypertrophy 💊Targeted therapeutic approaches 🔓Read more: t.ly/F2E3L