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1/ Excited to see this article published Nature Cancer. In a brilliant collaboration with Jürgen Ruland, Tim Wartewig, @Jay___Daniels, and Miriam Schulz discovered the mechanisms by which PD1 constrains T cell lymphomagenesis. nature.com/articles/s4301…

Pleased to share our new study in Nature Cancer highlighting a role for acetate metabolism in breast cancer and its impact on antitumor immunity. Special thanks to all of our collaborators and funders! National Cancer Institute Susan G. Komen The V Foundation for Cancer Research PA Breast Cancer Coalition @Wistar rdcu.be/dmrlm

ONLINE NOW Nature Cancer “Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer” by #ZacharySchug & Co. nature.com/articles/s4301… rdcu.be/dndEL

We are proud of the work one of our grantees, Schug Lab, is doing The Wistar Institute for breast cancer research. They've proven that the immune system can help kick Triple Negative Breast Cancer out! While still early, Our CSO, Dr. Susanna F. Greer, Ph.D., puts it into perspective!

I am excited to share our preprint "Identification of Fasnall as a therapeutically effective Complex I inhibitor." biorxiv.org/content/10.110… Several things from inside 👇 We asked a question: What happens with the polar metabolome of cancer cells when fatty acid synthase (FASN)

Happy to Schug Lab’s latest findings! We set out to establish the metabolic signature created by FASN inhibition and discovered, along the way, that three widely used FASN inhibitors likely do not inhibit FASN in cells. See project leader Dzmitry Mukha for a thread!

Happy to share our new paper in print today in Science Advances exploring nutrient utilization by CD8 T effector cells in vivo using infusion of 13C tracers. Great work by Eric Ma, Mike Dahabieh and collaborators at Van Andel Institute (VAI) and Agios. science.org/doi/10.1126/sc…

🔬 Excited to share Schug Lab’s latest findings at #ASMS2024! Join me at the poster session where we’ll delve into: 1. Targeted Metabolomics. 2. FASN (Fatty Acid Synthase) and fatty acid biosynthesis. 3. Coenzymes A, malonate, and succinate. 4. Mitochondria (should I add

Happy to report that our paper, where we grapple with the mystery of ACLY splice isoforms, is finally out! jbc.org/article/S0021-… @WellenLab Marmorstein Lab

Meet Nathaniel W. Snyder Nathaniel Snyder Winner of the 2024 Chemical Research in Toxicology Young Investigator Award! Read our interview here 🔗 go.acs.org/9HM

New preprint from the lab is online! The product of a stellar collaboration with Muir Lab, we explore a chemically defined physiologic media formulation based of the metabolite of tumor interstitial fluid (TIF, or “tumor juice”) and its effects on T cell function! A brief 🧵1/

No amount of alcohol is safe but the risk of limited consumption is limited but dictated by underlying conditions. This is an excellent summary of meta-analyses ⁦The New York Times⁩ nytimes.com/2024/06/15/mag…

My baby girl came on Monday night and closing the week with a first author paper from Russell Jones ! What a week!! Many thanks to everyone for all the efforts to get this paper out!!

linkedin.com/posts/the-wist…

Excited to share our latest study on ACSS1 and acetate metabolism in cancer, which was spearheaded by two graduate students in the lab. Stay tuned for more exciting news from the Schug Lab!

Thanks to support from The V Foundation for Cancer Research, Nan Zhang and Noam Auslander have been named as V Scholars and awarded $1.2 million in grant funding to support research that aims to improve existing cancer therapies. Our story: bit.ly/4gudEpE

Our work on metabolism of quiescent cells! A bit of a new area for us in collaboration with the Buckanovich lab

Happy to announce our collaboration with Kaechlab (Sue Kaech) on metabolic features of exhausted T cells is now out in Science Magazine. TL;DR they can't use acetate to fuel their function. Great work by Shixin Ma and Mike Dahabieh. science.org/doi/10.1126/sc…

NEW: Today, I’m releasing a Surgeon General’s Advisory on the causal link between alcohol consumption and increased cancer risk. Alcohol is the 3rd leading preventable cause of cancer in the U.S., contributing to about 100,000 cancer cases and 20,000 cancer deaths each year.