🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

This #FridayNightTalks Saurav Kumar from the Cooper Lab is sharing their research on the regulation of integrin by Cas during cell migration and Stephanie Dobersch from Human Biology’s Kugel Lab is discussing novel functions of LIN28B in pancreas cancer. Can’t wait!

Thanks Sue for the gift!!.Hutch Basic Sciences

My Post-Doc work on a long-standing question about Integrin activation and cluster formation is now available as pre-print. Comments and suggestions are welcome! Fred Hutch Cancer Center Hutch Basic Sciences #Cooperlab biorxiv.org/content/10.110…

Fred hutch with Helix Cloud Fred Hutch Cancer Center

Received NOA for R00, so lab is officially NIH-funded! Seeking postdocs interested in the broad areas of chromatin dynamics and transcription regulation. Fully funded positions available immediately. DM/email ([email protected])/ apply now at brahmalab.org. Please RT

My post-doc work is now online in #eLife. In this work, we show a two-step model for the initiation of integrin activation that starts with Cas clustering and phosphorylation. doi.org/10.7554/eLife.… eLife - the journal

Cas activates Inactive integrin. Inactive integrin activates Active Integrin. Cas activates Crk via binding. Crk activates Rac1 via binding. Rac1 acti... biofactoid.org/document/ac279…

Excited to see our latest paper featured on the eLife Cover Fred Hutch Cancer Center eLife - the journal

Beautiful summary of our work! Thanks Fred Hutch Cancer Center for selecting our work for the spotlight fredhutch.org/content/www/en… via Fred Hutch Cancer Center

The Berger lab is hiring! We have openings for post-docs and research techs right now! Feel free to apply or just reach out to chat. Our lab uses functional genomics to map cancer genotype to phenotype at scale. Come join us! Links in thread

Are you interested in strategies to control the spatial localization of your favorite protein at will? In our review, Saurav Kumar and I discuss the exciting development of chemical inducers of proximity to control subcellular protein localization. authors.elsevier.com/a/1ikNC3S7Zk9Z…

It was a pleasure to highlight the recent innovative studies from the labs of Stuart Schreiber and Matthew Meyerson (NICE approach), Steven Banik (TRAM approach), and Dan Nomura (covalent recruiters of 14-3-3 proteins).

Excellent review by Saurav Kumar and Behnam Nabet highlighting recent innovative approaches for chemically controlled protein relocalization. Thanks for also mentioning our self-localizing ligand approach!

Nature research paper: Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF go.nature.com/4aA7Rfz

Our latest work is out now in Cell Genomics. Hillary Layden and team use the dTAG system and deep genomic analysis to determine how wild-type and mutant FOXO1 control transcription in DLBCL. cell.com/cell-genomics/…

De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine biorxiv.org/cgi/content/sh… #bioRxiv

Excited to share our amazing work demonstrating that the degradation of KRAS G12V by dTAG induces antitumor immunity in a transgenic mouse model for lung cancer! jci.org/articles/view/…

Establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins - Behnam Nabet (Fred Hutch Cancer Center) oncodaily.com/science/behnam… #Health #Cancer #OncoDaily #Oncology #Research #Oncoproteins #TransgenicMice

In a study published today in Journal of Clinical Investigation, Behnam Nabet and collaborators describe how they used targeted protein degradation in mice to rapidly destroy lung and pancreas tumors caused by a variant of a commonly mutated, cancer-driving gene. bit.ly/42di54B

Targeting the most frequently mutated oncogene in lung adenocarcinoma promotes antitumor immunity. Hua Zhang Behnam Nabet & team UPMC report on a degradation system that disrupts KRAS G12V and abolishes lung and pancreatic tumors in mice: jci.org/articles/view/…