Thrilled to announce Professor Melanie Bahlo has been awarded the Genetics AustralAsia MJD White Medal in recognition of her outstanding contributions to the field of genetics research 👏👏

#genetics #science #medicalresearch #research

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What if 1 million scRNA-seq libraries can be prepared within $1k? Here we go 👉 21 million cells from 623 mouse tissues, spanning 5 life stages & 3 genotypes, all in a SINGLE study by ONE remarkable student Zehao Zehao Zhang from our lab Rockefeller University! shorturl.at/epsz7

Mold et al. show that within a cell type, clonally related cells exhibit heritable differences in gene expression that persist for years in vivo. Jonas Frisén Jeffrey Mold Jakob Michaelsson cell.com/cell-systems/f…

I am excited to share our latest research on the arachnoid barrier, a crucial yet poorly understood structure that partitions the CNS and the dura, out today nature. We discovered that gaps in this barrier allow communication between the CNS and the dura. nature.com/articles/s4158…

Intratumoral heterogeneity & Immune-tumor cell Zonation in #Glioblastoma

Integrative #SpatialTranscriptomics
#GeoMx #CosMx #Xenium +public #Visium

IDH1-WT tumors have more mesenchymal+progenitor-like cells than IDH1-mutant

Couturier for spatial cell type deconvolution #GeoMx …

Manuscript is now published in Genomics. Conclusions are unchanged but text and figures have been improved after peer review. A big thank you to my collaborators that made the study possible. doi.org/10.1016/j.ygen…

Just posted a preprint on our new spatial genomic recording system, baseMEMOIR.
biorxiv.org/content/10.110…
Motivation: Cells divide, differentiate, and migrate to form exquisitely organized tissues. Reconstructing the dynamic histories of individual cells, including their lineage…

A spatial transcriptomics method that…

🧪is easy to use
🔬has high resolution
🪙is cost-efficient
🌍scales to 3D

Just in time for Xmas:
Open-ST, a end-to-end, open-source method that checks all boxes, from the Nikolaus Rajewsky lab

📄Preprint: tiny.cc/openst

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Excited to share the first paper from the Tian Lab! With Xiaodong(Ethan) Liu we together established reference and standard to compared multiple sequencing-based spatial transcriptomic (sST) methods. Here is the preprint and some highlights (1/n) biorxiv.org/content/10.110…

A modular dCas9-based recruitment platform for combinatorial epigenome editing academic.oup.com/nar/advance-ar…

Amy Stephenson’s son Lachie was diagnosed with brain cancer at 19. Amy is making Lachie’s private diagnosis story public to help raise awareness & the urgent need for research funding. We’d love you to share these stories at thebraincancercentre.org.au

youtu.be/o9h8dvxTyjw

Good luck to Saskia Freytag and everyone taking on this huge challenge on Sunday, helping raise funds for vital brain cancer research BrainCancerCentre carriesbeanies4BC
To support Saskia head to pointtopinnacle2023.grassrootz.com/cb4bc/saskia-f…

Saskia Freytag Research Rockstar Brain Cancer Lab @wehi_research is running Point to Pinnacle with carriesbeanies4BC to help raise $ for research & support the fearless scientists like herself dedicated to solving this devastating disease. Support Saskia here: shorturl.at/iquH4

We were very proud to contribute to this paper that lays the groundwork for some amazing spatial imaging analysis of brain tumours. Congratulations to the team led by Saskia Freytag and sarah best

In our study published in Metabolites MDPI we compare MALDI-TOF to LC-MS and RNA-seq to find the best performing matrix. Recrystallised CHCA in positive polarity was most consistent in identifying altered metabolic activity in tumour and normal tissue. mdpi.com/2218-1989/13/1…

We have an incredibly exciting opportunity for a self-driven individual to come and work as an RA for us! Please retweet wehi.edu.au/careers/scient…

We’re turning 2 🥳 We’re excited about how far we’ve come but this is just the beginning. We’re bringing together the best & brightest minds working towards our vision: one day no lives will be lost to brain cancer. Help share this message & build on the momentum of The BCC

Check out our latest comprehensive review on #glioblastoma
It was great to be part of this collaborative national team!

New #MyelinPlasticity #GliomaNeuroscience review, written with brilliant postdoc Katy Taylor Kathryn Taylor (who is going on the faculty job market this year...) rdcu.be/doYBJ
nature.com/articles/s4158…

In 21 papers across Science, Science Advances, and Science Translational Medicine, researchers with the #BICCN consortium present an atlas of the human and nonhuman primate brain in unprecedented detail.

The results uncover the genetic organization of the human brain. scim.ag/4ro