Our #Autophagy paper is finally out! Congrats Parisa and a big thank you to all our collaborators. doi.org/10.1080/155486…

Our new article showing that Src controls mTORC1 activity nature.com/articles/s4146…

Our new article showing that ER-to-Golgi transport of lysosomal enzymes requires CLN8, a Batten disease protein. #lysosome #NatureCellBio nature.com/articles/s4155…

Dr. Paul Luzio's commentary on our article "CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis" doi.org/10.1038/s41556…

How can #mutations in a #protein that is not in the #lysosome result in a #lysosomalstoragedisorder? #CLN8 Sardiello Lab Nature Cell Biology BCMHouston TCHResearchNews bit.ly/2HIeKTl #Batten

Check out our new PNAS paper showing mTORC1-independent lysosomal depletion and abnormal glycogen storage in tuberous sclerosis pnas.org/content/early/…

Very proud and grateful for this award. A big thank you to all past and current lab members and our many collaborators!

Amazing work from the Tiemo J. Klisch lab

Super stoked to finally see my graduate school paper out today in Journal of Clinical Investigation. We show that a CLN6-CLN8 complex (that we refer to as EGRESS: ER-to-Golgi relaying of enzymes of the lysosomal system), recruits lysosomal enzymes at the ER to promote their Golgi transfer.

Our new article showing that CLN6 and CLN8 are obligate partners in the recruitment of lysosomal enzymes in the endoplasmic reticulum for Golgi transfer jci.org/articles/view/…

Congratulations @lakshyabajaj5 Sardiello Lab et al for solving the #CLN6 puzzle in #BattenDisease! Journal of Clinical Investigation BCMHouston TCHResearchNews

Solving the CNL6 mystery in Batten disease: bcm.edu/news/solving-t…

The Sardiello lab has just moved to Washington University in St. Louis. Contact us if interested to join as a post-doc, computer scientist, or lab manager/technician.

Amazing work from the Zhandong Liu lab! Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders genome.cshlp.org/cgi/content/lo…

Great work from the Michelle Hastings!

Very proud to share our latest publication on the discovery of #KCTD7 function and #calpain regulation by atypical ubiquitination. Massive kudos to superb lead author jaiprakash sharma whose visionary ideas and tireless efforts were crucial to make it happen! nature.com/articles/s4142…

Gene playing major role in neurological condition found | Baylor College of Medicine | Houston, Texas bcm.edu/news/molecular… via BCMHouston

BCMHouston Christian Schaaf Sardiello Lab Dr. Huda Zoghbi TCHResearchNews x.com/TCHResearchNew…

Our review on the autophagy-lysosomal pathway in LSDs and late-onset neurodegenerative diseases is out! annualreviews.org/doi/10.1146/an…