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NEW Review online: CD28 co-stimulation: novel insights and applications in cancer immunotherapy bit.ly/46qtBcP by Michael Lotze University of Pittsburgh, Scott Olejniczak Roswell Park & dimitris skokos Regeneron discusses CD28 as central to the success of current and future therapy

Two children with inflammatory bowel disease had neutralizing anti–interleukin-10 autoantibodies. One child had durable drug-free remission after B-cell depletion and an associated decrease in the anti–interleukin-10 titer. Read the Brief Report: nej.md/3y9T4ut

Great to see Roychoudhuri Lab across the pond in the USA!

Great to see this paper by Charlotte Imianowski and Paula Kuo finally in print! We observed that IFN-γ production by functionally reprogrammed Tregs promotes antitumor efficacy of OX40/CD137 bi-specific agonist therapies aacrjournals.org/cancerrescommu…

"Salty" 🧂🧂🧂papers out Nature Immunology! NaCl boosts CD8 T cell fitness and cytotoxicity for cancer immunotherapy Massive congrats Lugli Lab and Zielinski lab for this important discoveries nature.com/articles/s4159… nature.com/articles/s4159…

Our latest paper "NaCl enhances CD8+ T cell effector functions in cancer immunotherapy" is now out Nature Immunology nature.com/articles/s4159… 🥳🎉🍾. A 🧵:

Really interesting! Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice | Science Translational Medicine science.org/doi/10.1126/sc…

New NEJM A whopping (~90%) reduction of progression to Type 2 diabetes with tirzepatide (GLP-1 drug, dual receptor) vs placebo in a randomized trial of >2,500 participants with obesity, absolute reduction of 10/100 treated nejm.org/doi/full/10.10… by Ania M. Jastreboff, MD, PhD and

We've already seen remarkable results for lupus and other autoimmune diseases with CD19 B cell depletion therapy. Now add IgG4 related disease (which has no treatment) in a new randomized trial NEJM nejm.org/doi/full/10.10…

For readers interested in bispecific antibodies as cancer therapies, here's a comprehensive recent review nature.com/articles/s4157… rdcu.be/d1w34

Thirty years after the sequencing of the BRCA1 cancer-associated gene, access to genetic tests and awareness about its risks are still too limited go.nature.com/3BqFYdR

The skin — once thought to be a mainly passive barrier — can produce its own antibodies that fight off infections nature.com/articles/d4158…

Harnessing the biology of regulatory T cells to treat disease nature.com/articles/s4157… This new Review by Megan Levings et al. discusses approaches to enhance or inhibit Treg cell activity in allergy, transplantation, autoimmunity and cancer

T cells lead the charge against solid tumors nature.com/articles/s4301…

Thrilled to share our new paper in Nature Medicine! We analyzed 783 patients (2,200+ patient-years) receiving lentiviral or gammaretroviral T cell therapies and found no evidence of high-level insertional mutagenesis. nature.com/articles/s4159…

Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses Nature Microbiology Benjamin Beresford-Jones Wangmingyu Xia Pedicord Lab nature.com/articles/s4156…

Very excited about what this could mean for cancer immunotherapy! Amazing team effort by Puspendu Benjamin Beresford-Jones Wangmingyu Xia Clare Bryant ([email protected]) Justin Cross and Sarah Whiteside nature.com/articles/s4156…

Delighted to see our latest paper out in Nature Microbiology. We show that different types of LPS from the gut microbiota modulate efficacy of immunotherapy in melanoma. A potential new biomarker and enhancer for treatment response. Exciting for the field! nature.com/articles/s4156…

New paper from Pedicord Lab just dropped!! Congrats to all authors Sarah Whiteside Roychoudhuri Lab nature.com/articles/s4156…

This week's new issue of #ScienceTranslationalMedicine is out now! A pair of studies discovers a potential source of complications in Lyme disease and identifies a new antibiotic, microfluidic "smart" bandages manage chronic wounds in humans, and more. scim.ag/4lJ0xEz