This week: Dr. Sarah Whiteside and a team in the Roychoudhuri Lab found that CD4+ conventional #Tcells acquire suppressive functions upon #Treg depletion, limiting the efficacy of Treg-targeted therapies 📝 Science Immunology: bit.ly/3GVkCnO 🎧: bit.ly/3SlDqTU

Thanks for highlighting this insightful #Immunology research, Immunology Podcast! 💫 Check below to learn about Dr Sarah Whiteside and the Roychoudhuri Lab's findings, which highlight multiple layers of immunosuppression that can be overcome to enhance #Cancer #Immunotherapy ⤵️

Interested in tumour immunity, dendritic cells and immunotherapy? Excited to share our study on CCR7+ dendritic cells (DCs) in cancer out today, a joint effort between WithersLab and Clatworthy Lab. (🧵 1/8) nature.com/articles/s4146…

A beautiful piece of work @sciencemagazine led by my wonderful and longstanding collaborator Nan Shen on the important role of ZEB2 for pathogenic B cells (ABCs) in lupus.

Some tumors can release a virus-like protein that makes the immune system go haywire, with self-directed antibodies and neurologic deficits cell.com/cell/fulltext/… Cell Jason Shepherd University of Utah Junjie Xu

Research by Jason Shepherd U of Utah Department of Neurobiology University of Utah Health in Cell shows some tumors make a virus-like protein that triggers autoimmunity that attacks the brain, explaining why cancer triggers memory loss in rare cases. Way cool! ✏️Sophia Friesen healthcare.utah.edu/newsroom/news/…

T cell lymphoma mutations power adoptive T cell therapies! Excited to see this published! A true collaboration with friend and colleague @koleroybal and our students @jay__daniels and #julie_garcia. nature.com/articles/s4158…

In this case series of 15 patients with severe autoimmune disease, selective deep depletion of B lymphocytes with CD19 CAR T-cell therapy was effective in achieving clinical remission. Read the full article: nej.md/3UMQcMH

📢 Pls RT. I am recruiting a research assitant(s) at all levels of seniority to study T cell genome integrity in human cancer. Email me directly if interested.

Carrying a baby creates some of the same epigenetic patterns on DNA seen in older people go.nature.com/3Vyh8jN

Our review “CD4+ Regulatory T Cells in Human Cancer: Subsets, Origin, and Molecular Regulation” is out Cancer Immunology Research aacrjournals.org/cancerimmunolr…. We discuss Treg heterogeneity in cancer with focus on CCR8+ Tregs Cancer Research Institute

Biggest paper yet from the lab out now in Immunity! It is a massive #openscience resource on #tissueTregs, and what makes #Tregs tick in the #tissues. Spoiler-alert: Tissue Tregs are really different from what we all thought. 🧵 1/21 sciencedirect.com/science/articl…

Scientists Discover a New Hormone that Can Build Strong Bones | UC San Francisco Thank you ⁦Laura Kurtzman⁩ for a great summary of team effort with ⁦Tom Ambrosi⁩ ucsf.edu/news/2024/07/4…

Impressive results from the Rosenberg lab NCI Center for Cancer Research using TCR gene therapy targeting private neoantigens in patients with metastatic colorectal cancer. Tumor regression in majority of patients, including 3/7 (43%) objective responses. nature.com/articles/s4159…

NEW Review online: CD28 co-stimulation: novel insights and applications in cancer immunotherapy bit.ly/46qtBcP by Michael Lotze University of Pittsburgh, Scott Olejniczak Roswell Park & dimitris skokos Regeneron discusses CD28 as central to the success of current and future therapy

Two children with inflammatory bowel disease had neutralizing anti–interleukin-10 autoantibodies. One child had durable drug-free remission after B-cell depletion and an associated decrease in the anti–interleukin-10 titer. Read the Brief Report: nej.md/3y9T4ut

Great to see Roychoudhuri Lab across the pond in the USA!

Great to see this paper by Charlotte Imianowski and Paula Kuo finally in print! We observed that IFN-γ production by functionally reprogrammed Tregs promotes antitumor efficacy of OX40/CD137 bi-specific agonist therapies aacrjournals.org/cancerrescommu…

"Salty" 🧂🧂🧂papers out Nature Immunology! NaCl boosts CD8 T cell fitness and cytotoxicity for cancer immunotherapy Massive congrats Lugli Lab and Zielinski lab for this important discoveries nature.com/articles/s4159… nature.com/articles/s4159…

Our latest paper "NaCl enhances CD8+ T cell effector functions in cancer immunotherapy" is now out Nature Immunology nature.com/articles/s4159… 🥳🎉🍾. A 🧵: