Thank you NCI PhysicalSciences so much for mentioning our work at Paszek Lab with the support of Cornell PSOC. We're excited to develop this idea more!

Fantastic #glycotime work from Matt Paszek and coworkers ⁦Cornell University⁩, featuring glycocalyx editing with sialidases and mucinases 🤩

Immunoengineering can overcome the glycocalyx armour of cancer cells | Nature Materials nature.com/articles/s4156…

Now published in Analytical Chemistry -- check out our method to enrich mucins and probe the mucinome! #TeamMassSpec #glycotime Congrats again to Keira E Mahoney, Taryn Lucas, Vincent, and Krystyna!
doi.org/10.1021/acs.an…

Using bone matrix models & imaging in a Cornell PSOC funded study, Sangwoo (Steven) Park, Claudia Fischbach, et al. revealed a mechanism by which collagen mineralization promotes the resistance of #BreastCancer cells to attack by Natural Killer cells Wiley Biomedical Science bit.ly/3Itemop.

Thank you Matthew Macauley so much for this beautiful article! I really love the title 'A thicker skin for better immune evasion'

Today, NEJM published our clinical study of a novel #CARTCell in patients with #Glioblastoma . Early results with CARv3-TEAM-E suggest safety and bioactivity. Special thanks to all collaborators MGH Neurosurgery and Mass General Cancer Center!
nej.md/3VnjUIq

Interesting paper! Unraveling the impact of sialic acids on the immune landscape and immunotherapy efficacy in pancreatic cancer #glycotime
jitc.bmj.com/content/11/11/…

annualreviews.org/doi/abs/10.114…

Thank you so much for the support of the Coalition. It has been invaluable to this project.

Thank you for sharing our work! Nature Materials

Oh my god! Thank you Carolyn Bertozzi for sharing our paper! This makes my day!

First lab publication of 2024 in collaboration with Cornell CBE Matt Paszek! Siyoung Choi and Sangwoo (Steven) Park demonstrate that mineralized collagen increases tumor cell glycocalyx thickness and immune evasion in the context of bone metastasis. Read it here: onlinelibrary.wiley.com/doi/abs/10.100…

🎉🎉New Malaker lab preprint online now! We improved our mucin-selective enrichment technique to achieve higher throughput, lower sample input, and a higher number of mucins and O-glycopeptides detected! #mucinome #glycotime 🧵👇
doi.org/10.1101/2023.1…

I'm curious about any feedback from #Glycobiology #glycan #carbohydrate #glycotime community on Derda Lab preprint on DNA-encoded liquid #lectin arrays (LiLA). [LiLA] non-lineary amplifies detection of compositional differences of the cellular #glycocalyx biorxiv.org/content/10.110…

Mucins on tumor cell surface protect tumor cells from killing by NK cells but this glycocalyx barrier can be breached by surface-attached enzymes on NK cells. Sangwoo (Steven) Park (work was done in Paszek lab Cornell) #cellbio2023 biorxiv.org/content/10.110…

Proud of Matt Bell who published his graduate work on leucine zipper cytokine receptors today in BME!
nature.com/articles/s4155…

Fantastic line-up of speakers. Please join us to discuss the various features lipids can do in the cells. Co-chaired by Sarah, Chi-lun, Chris Obara, Itay, and myself Sarah Cohen CC_Lab Itay Budin #cellbio2023 Mon, Dec 3 at 3:30PM, Room 354A