I’m excited to celebrate this milestone the with most amazing lab ! Thank you all so much for your support, scientific advice, friendship, and fun times over the years 😊

Rockclimbing, awesome Brittany is now Dr. Schutrum! So very excited and proud about this 5th Fischbach Lab member who graduated with flying colors over the past year! Cornell BME

Congrats to Brittany for a fantastic defense of her PhD thesis examining the role of hyaluronic acid in breast cancer invasion! We have been so fortunate to have Brittany in our lab as a scientist, mentor, and friend #PhDone 🎊

Using microfluidic tumor-vasculature models and computational flux balance analysis, endothelial cells were found to induce breast cancer invasion that is facilitated by metabolic reprogramming. Claudia Fischbach Fischbach Lab Matt Tan aippub.org/3IfV4m6

What better way to commemorate an amazing defense by Matt Whitman than with a celebratory cake shaped like a chicken?! Props to my co-conspirator Brittany for making this avian surprise a reality 🐓

Congrats to Dr. Matt Whitman for a fantastic defense of his thesis on the protective role of bone mineral density in breast cancer metastasis. We’ve been fortunate to have such an outstanding scientist and human in our lab!

May I introduce Dr. Matt Whitman - expert in the role of mineral density in bone metastasis, terrific communicator and wonderful lab member. #proudPI Cornell BME

I am excited to share our work at Paszek Lab and Fischbach Lab at Cornell University which was accepted by Advanced Sci News. This paper demonstrates how bone matrix mineralization can promote tumor cell evasion from NK-cell-mediated cytotoxicity by altering glycocalyx composition and thickness

I am late with sharing some of the exciting results our lab has published in the past 2 months to improve understanding of how cell-ECM interactions affect different aspects of cancer. Interested? Follow🧵👇

First lab publication of 2024 in collaboration with Cornell CBE Matt Paszek! Siyoung Choi and Sangwoo (Steven) Park demonstrate that mineralized collagen increases tumor cell glycocalyx thickness and immune evasion in the context of bone metastasis. Read it here: onlinelibrary.wiley.com/doi/abs/10.100…

A little late on this, but happy with the way this final first-author paper from my PhD turned out! It was a great opportunity to integrate a diverse set of tools from across disciplines. Thanks again to everyone who helped out with this!

One final paper from Fischbach Lab in 2023! Matt Tan et al. investigated changes in tumor cell metabolism that occur during invasion toward engineered microvessels using metabolic imaging, metabolomics, and flux balance analysis. Read it here: pubs.aip.org/aip/apb/articl…

New paper in collaboration with MIT Dept of BE Forest White Lab. Adrian Shimpi et al. examined broad differences in protein phosphorylation in tumor cells and identified LYN as a mediator of increased migration speed and persistence on matrix vs. plastic: pubs.acs.org/doi/full/10.10…

Fischbach Lab bringing in the holiday season in style 🎉

Check “Tooling up against mechanobiological orthodoxy,” highlighting our recent work on in vivo measurement of solid stress along with great studies from Fischbach Lab and Dave Mooney Lab!

nature.com/articles/s4155…

Our latest publication on the relationship between bone mineralization and tumor cell #mechanosignaling has been featured in Nature Biomedical Engineering alongside other great recent studies from Dave Mooney and Hadi T. Nia. Check it out here: nature.com/articles/s4155…

Fischbach Lab craft night has never smelled so good! Making candles was a great exercise to put our lab basics to the test 🧑‍🔬🕯️

In a study funded by Cornell PSOC, Matt Whitman, Fischbach Lab, et al. showed that bone-matrix mineralization suppresses mechanosignalling and metastatic progression in preclinical models of #BreastCancer Nature Biomedical Engineering go.nature.com/3OWq0Ll. #BCSM #BreastCancer AwarenessMonth

Come hear about how the biophysical properties of hypertrophic adipocytes (which develop with weight gain) influence breast cancer invasion. The Biomedical Engineering Society tumor microenvironment session starts at 8:00 AM PDT on 10/12. And hear from superstar Brittany before me as a bonus!