In a new Science study, researchers introduce GAIA, a statistical approach that seeks to learn the geographic position of every genetic ancestor of individuals included in a genome dataset. Learn more ⬇️ 📄: scim.ag/4l79zLb #SciencePerspective: scim.ag/41Owy6f

Looking for a new research assistant to join our team Heart Research Institute . If you have an interest in the #heart and #cancer please apply. ISHR Australasian Section

Lactate controls cancer stemness and plasticity through epigenetic regulation dlvr.it/TJwtQM

Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming dlvr.it/TJyJMT

New online! The genetic basis of human height bit.ly/4crXfl6

🧵 Should you integrate single-cell RNA-seq datasets or not? You've got PBMCs from multiple donors. Merge them—or keep them separate? Let's break it down.

Check out this new Cleveland Clinic study uncovering glucose metabolism in focal cortical dysplasia is linked to epigenetic GLUT1 regulation. Congrats to Chaitali and team led by Imad Najm Imad Najm ClevelandClinicNews link.springer.com/article/10.100… #epilepsy #neuroepigenetics #GLUT1 #FCD

New! Online now: O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles dlvr.it/TK4lJ4

Our lab has identified a new epigenetic mechanism and a druggable target in #HFpEF. Extremely thankful to my amazing team and our fantastic collaborators! Circulation Research University of Zurich Unispital_USZ CTEC - Zurich University Heart Center Paneni Lab ahajournals.org/doi/10.1161/CI…

Proud to share our latest work! Out today in Circulation Research CTEC - Zurich University Heart Center Francesco Paneni Shafeeq mohammed Natalia Atzemian Era Gorica Marialucia Telesca Alessandro Mengozzi Alessia Mongelli Ludovica Di Venanzio

*Diabetes impairs blood vessel growth, worsening PAD outcomes *Study finds high glucose boosts SETD7, increasing SEMA3G-an angiogenesis blocker-restoring vessel formation in diabetic cells, mice, and patients *Targeting SETD7 may offer a new epigenetic therapy for diabetic PAD

Epigenetic changes affect the function of the glucose transporter DNA in endothelial cells from FCD2tissue….The role that decreased glucose tissue concentration in FCD 2 tissue remains unknown… future research is designed to uncover the significance and mechanisms in #epilepsy!

Please all join our General Assembly ISHR2025 in Nara in Nara - room A&B today at 14:00! ISHR Australasian Section ISHR North American Section 国际人权服务社(ISHR)

"Scalable co-sequencing of RNA and DNA from individual nuclei" - cool new method! nature.com/articles/s4159…

🚨 Out now in Circulation Research 🚨 So proud with Maria Kontaridis to launch this Compendium on Interorgan Crosstalk in Heart Failure & Cardiometabolic Disease. Heart failure it’s systemic. Multiorgan. Dynamic. Circulation Research DZHK Germany Deutsches Herzzentrum der Charité Max Delbrück Center

Still buzzing from the 20th IPITA Congress in Pisa! Too many highlights to name, one standout was Dr. Deng’s talk on Chemical Reprogramming for Cell Fate. Stellar program & speakers, meeting new friends and staying at the historic Galilei residence, home of Galileo’s family!

Stem cell derived islet therapy restores insulin in people living with T1D 🔹 100% showed C-peptide response 🔹 100% avoided severe hypos + HbA1c <7% 🔹 83% achieved insulin independence at 1 year 🔹 All received single infusion + immunosuppression nejm.org/doi/full/10.10…