How do #CancerStemCells drive tumor growth & survival? CGHubert Shaun Stauffer Justin Lathia, PhD 🧠🕺🏽 explore a #PLOSBiology #ColonCancer study revealing a pathway that links epigenetic regulation to self-renewal & resistance Paper: plos.io/3ZliKgx Primer: plos.io/3RpjoYK

Fun C3TD.com group outing at CLE Rocks!

Our collaborator Shaun Stauffer is a corresponding author. READ ⬇️ rdcu.be/dnP1C

🧀 Happy Playoff Victory Monday (to those that celebrate)

Charles Ryan Rana McKay, MD, FASCO VA Research Prostate Cancer Foundation ASCO Neeraj Agarwal, MD, FASCO Andrew Armstrong Shaun Stauffer Sumanta K. Pal, MD, FASCO For reference here is the mechanism we identified over a decade ago studied in Rana McKay, MD, FASCO’s over 5000 man #MillionVeteranProgram study. It took a little while to get this far! And thanks to PCF Science and National Cancer Institute support along the way! Veterans Affairs cell.com/fulltext/S0092…

Amazing visit and Symposium with NCI Chemical Biology Consortium colleagues and attendees. Many thanks to our hosts and co-chairs! Alex Waterson @cispt2 Sanford Burnham Prebys Also great work Dr. Jesse Coker representing lab and sharing profile of our Citron Kinase Probe C3TD879

Took a while to get out, but I’m proud of our work reporting first-in-class selective inhibitors of Citron Kinase (CITK). C3TD879/-N approved and will be available from Structural Genomics Consortium (SGC)’s Donated Chemical Probe program very soon! Jonty Macdonald Shaun Stauffer pubs.acs.org/doi/abs/10.102…

Congrats CitK team, novel target with lots of twists and turns, still more to unravel. Grateful to projects leads Jesse, Josh, Tarun, and Jonty for their tenacity!

compounds patiently waiting…

C3TD picnic at CWRU Farm! Great to meet families and enjoy some beautiful NE Ohio weather with fun games and great company.

Awesome finish to summer intern program at C3TD. Thank you Joseph, Eric, Annabella, Emma, and Anne for contributing to our mission and research! Best wishes for your next chapter!

newsroom.clevelandclinic.org/2024/09/23/inn… Shaun Stauffer Desai Sethi Urology Institute Cleveland Clinic

linkedin.com/posts/shaun-st…

Recent visit to Cleveland Public Library open house celebrating 100yr mark, I stumbled into periodicals and re-discovered why printed journal collections inspire!! Grabbed ChemRev 2007 issue to find Andrew Hamilton PPI review…challenges to drug PPI’s continue in 2025!

New crystals from structbio team C3TD, group outing May 2025. Pushing frontier for future anti-cancer therapies.

Our WDR5 journey in #GBM continues, happy to highlight a new bioRxiv on a new series of inhibitors in collaboration with the Cleveland Clinic Research team - Shaun Stauffer Dr. Jesse Coker Samuel A. Sprowls, PhD Anthony R. Sloan, Ph.D. biorxiv.org/content/10.110…

Akron relay marathon Center for Therapeutics Discovery team killed it this weekend, great job Nancy, Bin, Jesse, Mike, and Tony!

September highlight- Akron relay marathon. C3TD runners killed it!

Amazing two days at WashU attending Academic Drug Discovery Consortium Colloquium, C3TD presented few vignettes and made many great new contacts!

Superhero’s and compounds rising above streets in CLE, sights from fall bike commute to C3TD office ⁦Cleveland Clinic Research⁩