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President’s Award for the best fundamental work from World Muscle Society at the #WMS2022 in Halifax to Judith Reinhard for her work on the development of a potential treatment for LAMA2 MD. #LAMA2 #MDC1A SEAL Therapeutics AG. Congratulations!👋👋👋

Targeting protein breakdown in muscle atrophy? Proceed with great caution! The UPS preserves proteostasis at the expense of muscle growth in response to sustained mTORC1 activation. Communications Biology: rdcu.be/cYpXV. Great collaboration with @DavidjGlassMD & @ZavolanLab

Thinking about interrogating the function of your candidate genes? Check out our latest preprint that describes a fast, highly efficient and multiplexable system for skeletal muscle fibers. doi.org/10.1101/2023.0… Thanks to Grimmlab Randall Platt for the great collaboration!

Bad news: LAMA2-related muscular dystrophy not only affects muscle but also the peripheral nerve. Good news: linker proteins also do the trick there. Checkout our latest work PNAS Nexus qrco.de/bdsxvx. Thanks to Pawel Pelczar Universität Basel Emanuela and Stefano Stefano Previtali

Wer an LAMA2-Muskel­dystrophie leidet, dem fehlt das Gerüst-#Protein Laminin α2. Via #Gentherapie mit künstlich generierten Linker-#Proteinen will SEAL Therapeutics (SEAL Therapeutics AG), ein #Spinoff der Universität Basel, dessen Funktion ersetzen… @SigridMaerz fragt nach: laborjournal.de/editorials/278…

John’s enthusiasm for neuroscience and dedication to teaching was an inspiration to me and so many students all over the world. I will always be grateful for his support and mentorship when I started as a young group leader at the Biozentrum.

Be part of our pioneering efforts towards #bioxolography and join our new SNF Sinergia consortium with the research groups of Robert Katzschmann Soft Robotics Lab at ETH Zurich (ETH Zurich), Markus Rüegg Rüegg Lab (Universität Basel), and Matteo Moretti (Ente Ospedaliero Cantonale). Revolutionize bioprinting with us!

If you are interested in addressing molecular mechanisms involved in skeletal muscle function, check this out nature.com/articles/s4146…. Congrats to Marco Marco Thürkauf and thanks to our collaborators Dirk Grimm Grimmlab and Randy Platt Randall Platt.

Congratulations to Marco Thürkauf for successfully defending his PhD thesis „Decipering the function of candidate genes in skeletal muscle aging using AAV-CRISPR/Cas9“. Biozentrum, University of Basel Universität Basel #phdone All the best for your future! 🎓🎉

Win-Win in der Muskelforschung: Forschende Biozentrum, University of Basel haben eine Methode entwickelt, die die Zahl der benötigten Versuchstiere stark reduziert. #Forschungsethik #CRISPR #3R unibas.ch/de/Aktuell/New…

Rüegg Lab has developed a new method using #CRISPR/Cas9 to study the function of genes in muscle fibers. It is efficient and reduces the number of experimental animals. The method implements the #3R principles. Biozentrum, University of Basel University of Basel Nature Communications ow.ly/vBZt50PVSVq

Zum #TagDerSeltenenKrankheiten rücken wir die LAMA2-Muskeldystrophie in den Fokus. Bislang gibt es keine Therapie für die genetisch bedingte Erkrankung. SEAL Therapeutics AG, ein Start-up der Universität Basel, verfolgt nun einen vielversprechenden Ansatz. 🧵 1/6 unibas.ch/de/Aktuell/New…

On #RareDiseaseDay, we are putting the spotlight on LAMA2 muscular dystrophy. As yet, there are no effective therapies for this genetic disease. SEAL Therapeutics AG, a University of Basel start-up, is now pursuing a promising approach. 🧵 1/7 unibas.ch/en/News-Events…

Check out our latest preprint where we use single-nuclei RNA-seq to study gene expression at the neuromuscular junction: biorxiv.org/content/10.110… The paper also characterizes three novel NMJ proteins including the Golgi-associated and MuSK-binding protein PDZRN4.

Really happy to share our study on Myotonic Dystrophy Type 1 now in #SkeletalMuscle. Very proud of the work performed by Denis Falcetta, Sandrine Quirim, Florent Chabry, and all other group members and collaborators unige Biozentrum, University of Basel. Thanks to all ! …eletalmusclejournal.biomedcentral.com/articles/10.11…

It was great to host Téléthon Suisse in our lab and share insights into our research on LAMA2 muscular dystrophy (in French) Swiss Foundation for Research on Muscle Diseases SEAL Therapeutics AG Reportage sur deux laboratoires de recherche à Bâle youtu.be/Gt4Zqpr_ZDg?si… via YouTube #LAMA2 #MDC1A

Check out our latest publication where we use single-nuclei RNA-seq to study gene expression at the neuromuscular junction: nature.com/articles/s4146… The paper also characterizes three novel NMJ proteins including the transcription factor ETV4 and the MuSK-binding protein PDZRN4.

If you're using AAVs to develop a gene therapy or to study gene function in skeletal muscle, then this may be of interest to you. In our latest work, we show that AAVs commonly used to deliver transgenes to muscle fibers also target mononuclear cells: cell.com/molecular-ther…

Myc and muscle growth: necessary in muscle stem cells, dispensable in muscle fibers and harmful if overexpressed. Check out our latest work rdcu.be/eggcw in Nature Communications, where we explore the role of Myc in muscle growth and more.

New study by Rüegg Lab challenges previous view about the muscle growth factor #Myc! This protein is dispensable for #musclegrowth. High Myc levels disrupt muscle fiber structure and function. University of Basel Swiss National Science Foundation Nature Communications ow.ly/mXQm50VzRkP