Check out our latest paper, published Nature Communications. We show that STING activation induces IL18 secretion and thereby enhances CAR T function. Great collaboration between @CarlHJune lab and James Chen UT Southwestern Medical Center.
Penn Medicine Penn Medicine MD Penn Postdoctoral Association
nature.com/articles/s4146…

Now in Science Immunology: HUST researchers analyze #blood & #CSF from patients w/ #neurological #autoimmune disease ( #NMOSD ) undergoing #CARTCell therapy. These CAR T cells show differences w/ CAR T cells from treated #myeloma & #lymphoma patients!

bit.ly/SciImm_adj9730

A fantastic postdoc opportunity to bridge two groups at Sanger. We have an exciting project, co-developed with Carl Anderson to deploy large scale CRISPR and single-cell transcrptomics to understand IBD genes in Tregs. We're looking for an immunologist to lead this effort!

Alyssa is the first patient to receive a base edited therapeutic (triply base edited CAR-T cells that cleared her T-cell leukemia), doing well now more than two years post-treatment thanks to the efforts of Waseem Qasim’s team and GOSH.

Selective CAR-T cell mediated B cell depletion suppresses interferon signature in SLE JCI insight Gerhard Krönke
insight.jci.org/articles/view/…

Unreal!

Bombs won’t end Hamas - only a better idea can do that.

It’s time for the international community to push intensely for a two-state solution and an end to this conflict which began in 1948 which is dividing the world and making it a less safe place

Kids get a lot less car sick in a #bakfiets bike!

Genotyping of targeted loci with single-cell chromatin accessibility (GoT–ChA) shows that JAK2V617F mutation leads to cell-intrinsic, cell type specific epigenetic rewiring influencing inflammation and differentiation nature Dan Landau Franco Izzo
nature.com/articles/s4158…

Attia was a postdoc with me at NCI.

One example of many emerging NK cell-mediated regulatory roles in constraining T cell immunity against cancer. Science Immunology #NK_cell science.org/doi/10.1126/sc…

'Research is messy. … Trying to protect students from that reality does them a disservice.' #TeacherAppreciationWeek scim.ag/6SQ

UPenn and Stanford analysis finds no secondary cancer cases directly due to CAR-T – Endpoints endpts.com/upenn-and-stan…

While some patients developed solid tumors or leukemia post-CAR T, no evidence found that therapy caused these secondary cancers. As CAR T use expands, PICI remains focused on enhancing their effectiveness against solid tumors. (2/2) endpts.com/upenn-and-stan…

A sobering read..

World’s top climate scientists expect global heating to blast past 1.5C target - tragically not unexpected theguardian.com/environment/ar…

We owe Israeli citizens external critique of their state’s actions - this is not antisemitism - rather it aims to spare Israel the moral hazard of what it is now engaged in in #Gaza .

Academic institutions must contribute moral leadership during difficult times. Objection to Israeli state actions does not comprise antisemitism. Attempts to blur these distinct entities aim to suppress freedom of speech.

AlphaFold 3 is here - now capable of joint structure prediction of complexes including proteins, nucleic acids, small molecules, ions & modified residues nature.com/articles/s4158…
nature

Take your Vitamin D! It confers greater immune-dependent resistance to transplantable cancers and augments IO responses. Vit D acts on intestinal epithelium to alter microbiome in favor of Bacteroides fragilis, a positive regulator of cancer immunity. sciencemagazinedigital.org/sciencemagazin…