Now on Youtube: ML in Intensive Care

In our latest Revolutionizing Healthcare session, Paul Elbers, Robert David Stevens, MD, MBA, FCCM, Tobias Gauss, and AriErcole discuss adoption challenges for ML in intensive care, data gaps, challenges to the ML community, and LLMs:

📺youtu.be/jiY6QhuUIu8

Mechanical ventilation is central to brain injury resuscitation. Thanks to this work in ATS Blue Journal we learn that as in other populations higher driving pressures are linked to worse outcome. Well done Sarah Wahlster, Chiara Robba and team!
#enio #ICU
atsjournals.org/doi/10.1164/rc…

Delighted and proud that one of my Johns Hopkins BME students just clinched the prestigious PD Soros Fellowships fellowships. Congratulations shubhayu bhattacharyay !!

#Traumaticbraininjury #AIinMedicine #PrecisionMedicine

hub.jhu.edu/2024/04/18/joh…

The venue is in Psychiatry & Neuroscience Insitute of Paris on the 27 and 28 of June. Register now at nicis.fr !
Sarah Benghanem Benjamin Rohaut Aurélien Mazeraud SRLF CômeBureau ANJMIR

jan claassen Jaideep Kapur L J Hirsch L Naccache M Walker R Nabbout F Bartholomei M Gavaret M van Putten N Gaspard Weiss Nicolas A Vezzani A Hanin Yann N R Khazipov Simon Shorvon V Navarro J Horn Robert David Stevens, MD, MBA, FCCM Romain Sonneville and T Sharshar

We are very glad to announce the #NICIS2024 congress. Top notch translational neuroscience applied to neurocritical care. This year's topic is Seizures in the ICU with an impressive set of international speakers !

Neurogenerative disorders are prevalent and challenging to diagnose, treat, prognosticate. Here disease trajectories are defined using NLP is applied to clinical descriptors with brain pathology as ground truth. Phenomenal work in Nature Medicine rdcu.be/dBxa2

Neuromonitoring in the ICU - what, how and why? pubmed.ncbi.nlm.nih.gov/38441121/
#neuromonitoring #intensivecare #ICU

Naming and classification of diseases (nosology) are antiquated and will evolve radically as mechanisms are elucidated. We must lay the foundation for a new language in medicine that maps to biological reality rather than pre-conceived syndromes
nature.com/articles/d4158…

Communicate with unresponsive brain-injured patients? What are the top priorities in brain-computer interface research for patients with disorders of consciousness? A scientific roadmap from the Coma Science Working Group of the Curing Coma campaign

rdcu.be/dxSEu

We are on Intensive Care Medicine discussing CO2 in brain injured patients!

Incidence and Outcomes of Acute Respiratory Distress Syndrome in Brain-Injured Patients Receiving Invasive Ventilation: A Secondary Analysis of the ENIO Study - PubMed pubmed.ncbi.nlm.nih.gov/37563968/

Early insight on language acquisition using a deep neural network trained with 61h of data recorded with a camera mounted on a single child between the age of 6 and 25 months
#DeepLearning #DataScience #computationalneuroscience
science.org/doi/10.1126/sc…

Do we really know how cells work? Could a computational model help? A solution might reside in digital twins trained with high-dimensional structural, functional, and perturbational data. On the cusp of a new paradigm in biology and medicine doi.org/10.1016/j.cell…

How to optimize mechanical ventilation in neurocritical care? What should be the PaCO2 target range? An analysis of a large multisite dataset provides insight on a non-linear relationship. Great work from Chiara Robba and the ENIO team in Intensive Care Medicine
rdcu.be/dxuBj

PaCO2 in acute BI
🧠 extreme hypo/hypercapnia associated with ⬆️ mortality (whole cohort)
🧠 mild hypocapnia better tolerated, especially in #TBI
🎯 specific targets should consider ABI type & physio/neuromonitoring data
🔓 rdcu.be/dxuBj

ENIO
🔓 rdcu.be/dxuCa

Honored to be in Houston to give Grand Rounds at @MDAnderson. Thanks to TJ Gan, M.D. and the fabulous team in the Division of Anesthesiology, Critical Care, and Pain Medicine. Also delighted to reconnect with Jeff Siewerdsen at the Institute for Data Science in Oncology

Robert David Stevens, MD, MBA, FCCM So neuroprotection studies should focus on subgroups like this, an example of predictive enrichment😄

Deep learning model trained with preoperative 12-lead ECG discriminates postoperative mortality with an AUC of 0.83, significantly higher than the current benchmark model.
#healthai #precisionmedicine
sciencedirect.com/science/articl…