How does the nucleus deform in a contracting cardiomyocyte, and how do loss/mutation of lamin A/C and LINC complex disruption affect this? Check out this work by Daria Amiad Pavlov and the Ben Prosser, with contributions from ShenoyLab, Raj Jain, and our lab. #mechanobiology #lamin

Rat cardiomyocyte stained with SiR-actin (magenta) & hoechst (cyan) imaged at high frame rate showing nucleus strain during contraction! Don't miss your chance to read the amazing associated preprint "Microtubule forces drive nuclear damage in LMNA cardiomyopathy" from

Deadline alert! March 17th is the last day to submit your abstract for oral presentation consideration at the Gordon Research Conference on Cardiac Regulatory Mechanisms this June. Don't miss your chance to showcase your research! #CardiacScience #GRC #GRS grc.org/cardiac-regula…

Happy #RareDiseaseDay! Lucy, 5, #STXBP1, working HARD on that first word (Hiiiiiii!) and independent steps. Effortlessly bringing all the sunshine ☀️

These are BEAUTIFUL 👏tissue mechanics in living myocardial slices by the Caporizzo Lab. They define (with precision) how targeting microtubules can improve cardiac function by facilitating relaxation and early diastolic filling.

Don't miss the premier conference for fundamental and translational cardiac research! Program in link, still with open talk slots to be selected from abstracts. #CardioTwitter Rong Tian, MD PhD Kim Hellgren Leslie M. Kennedy 👩🏾‍🔬 grc.org/cardiac-regula…

Keep going Brett.

Happy birthday Lu! 6 years - and now standing by yourself! I have too many feelings to tweet, so I'll just say THANK YOU to everyone who has supported Lucy, or who is fighting to improve the lives of those with #raredisease. Keep going.

Check out our new paper Journal of Clinical Investigation by the great Rami Haddad and Omer Sadeh. We show that the protein RPSA is required for ribosome localization, localized translation, and the maintenance of the sarcomere. dlvr.it/T6vjhn

Ben Prosser Rong Tian, MD PhD The traditional #GRC soccer game ⚽️ 🥅 #GRCcardiac2024 #CardiacRegMechanisms #ColbySawyerCollege

Want to know more about what ENDD is doing for rare 🧠disorders like SynGAP Research Fund (SRF) and stxbp1? Updated website here! endd.med.upenn.edu Children's Hospital Penn Medicine DAVIDSON LAB Ingo Helbig Liz Heller

Small molecules that inhibit vasohibins and alpha-tubulin #detyrosination can promote myocardial relaxation and counteract heart muscle cell stiffness in a rat model of #HeartFailure with preserved ejection fraction. Margulies Lab @Prosser scim.ag/7Nf

$$$ for #RareDisease research! RFAs for 35 different rare disorders through the The Orphan Disease Center @ UPenn, including 2 x $70K grants available to stxbp1 courtesy of Lulu's Crew :) Info and app link here: bit.ly/MDBR2024RFA