📢Our rapid response to the COVID-19 pandemic on bioRxiv „Synthetic nanobodies targeting the SARS-CoV-2 receptor-binding domain“ The sequences of the 63 unique anti-RBD #sybodies selected within 12 working days are open access. biorxiv.org/content/10.110…

Sybody Generation Toolbox Deposited by Seeger Lab The Seeger Lab has established a protocol to select synthetic #nanobodies – called sybodies – against membrane protein targets. This collection contains all plasmids needed for sybody generation. hubs.ly/H0pzp350

📽️IrtAB, an ABC transporter with an exporter fold, imports iron-bound mycobactins while the cytoplasmic domain (blue) reduces it to facilitate iron release. Our structure reveals a partially collapsed inward-facing substrate-binding cavity. Full story: nature.com/articles/s4158…

📢Further progress at our COVID-19 front: six sybodies now characterized; decent binding affinities (20-180 nM); five sybodies strongly compete with RBD binding to ACE2; a sybody pair can bind simultanously. Find the updated manuscript on bioRxiv: biorxiv.org/content/10.110…

The Seeger Lab in 2020😀

Currently our institute is an island on the ocean of constructions🚧 Imre recorded and edited a video of our old lab building being teared down. CAUTION: catchy tune!😅😅 (song credit: Parry Gripp)

Agonist-bound OX2R cryo-EM structure in complex with a conformation-specific sybody👏 nature.com/articles/s4146… We are proud to have contributed to this seminal study of Kaspar Hollenstein from Merck by generating a conformation-selective high-affinity (600 pM) sybody💪

Continuous flexibility is the next frontier for #cryoEM. We are thrilled to introduce 3D Flexible Refinement, a new deep generative model that solves both detailed non-rigid motion, and high-res structure of flexible proteins!! biorxiv.org/content/10.110… cryosparc.com/3dflex 1/

I am more than happy to share this beautiful story that was a big part of my PhD at @HeinemannLab University of Groningen GBBResearch authors.elsevier.com/a/1c%7EG58jWWJ…

Proud to share our latest cryo-EM structures on a yet unexplored, teeny-tiny member of the XKR family 🥳❄️🔬

Nice structural work on a new protein family from the Dutzler lab! 👏🏻 Pushing the size limit of membrane protein cryoEM! 👀 Great use of sybodies (Seeger Lab) and cryoSPARC (Structura Biotechnology). biorxiv.org/content/10.110…

Happy to say our cryo-EM structure of Mtb MmpL3 is now out in Structure! (authors.elsevier.com/sd/article/S09…). Thank you to all co-authors for your hard work (Justin Deme, Susan Lea, Philip Fowler, Simon Newstead & twitterless Joanne Parker)!

TTYH proteins, AKA Tweeties, have long been mistaken for chloride channels. Unraveling the possible functional relation of the Tweety family to lipid transport and metabolism in our new paper out in Nature Communications: nature.com/articles/s4146…

Our latest preprint is out🥳 doi.org/10.1101/2021.1… We performed DMS on EfrCD to determine the drug efflux activity profile of 1539 single variants! Many interesting findings🔎, amongst which, that single mutations (!) can convert the exporter into a drug-specific ABC importer!

Fantastic talk by ⁦Gonda Imre⁩ at #TransCure2022 ⁦@NCCR_TransCure⁩ ⁦Seeger Lab⁩ #Switzerland!

Fantastic talk by ⁦Monique Straub⁩ #Switzerland @uniofbern #unibern! Great program Prof. Hugues Abriel @[email protected] #TransCure2022!

Fun experience in VR, you can even dance with your proteins! #TransCure2022

Sonja Rutz from Dutzler Lab presents "Structure of a volume-regulated heteromeric #LRRC8 #ionchannel". Amazing structures! #TransCure2022

Check out our Nature Metabolism paper that advances the knowledge of eukaryotic cell cycle. 2/n nature.com/articles/s4225… @HeinemannLab GBBResearch University of Groningen Horizon Europe 🇪🇺 Marie Skłodowska-Curie Actions

I‘m happy to share our work on laser flash melting to overcome preferred orientation in cryo-EM samples! 🥳❄️🔬 More infos on the underlying mechanism of particle redistribution and the use for preferred orientation issues in the 🧵 or here: biorxiv.org/content/10.110…