1/ Thrilled to share our latest publication in @JCI on humans with inherited IL7 deficiency! 🧵👇 jci.org/articles/view/…

Shortly after a patient received CAR T-cell therapy for relapsed CNS lymphoma, an aggressive CAR+ T-cell lymphoma was diagnosed. Subsequent analysis revealed the presence of an abnormal clone in an early apheresis specimen. Read the Brief Report: nej.md/3BuToVM

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Bravo Marco Rodari & @marparl1 !

tidyplots Time to say goodbye to ggplot2?🫡 "a significant reduction of code complexity" vs ggplot2 cran.r-project.org/web/packages/t… Jan Broder Engler bioRxiv 2024 biorxiv.org/content/10.110…

[LAURÉATS 2024] 🏅Félicitations à @FRLab1, lauréat du prix des divisions de l'Académie nationale de médecine pour ses travaux "#Maladie auto-#immune de l'#enfant" Institut Imagine Inserm @Univ_Paris Hôpital Necker AP-HP 🛜 bit.ly/3ZYIAZG

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? Latest from us. Published today. News here cuimc.columbia.edu/news/what-happ… article here: nature.com/articles/s4158… O'Jay Stewart BogunovicLab and a huge international team thank you 🙏🏼 Columbia Children's Health Lipschultz Precision Immunology Institute

In Journal of Experimental Medicine, Quentin Riller, Rieux-Laucat et al. show that IKKα kinase deficiency causes syndromic #immunodeficiency & immune dysregulation as a consequence of a major defect in the non-canonical NF-κB pathway and a partial defect in the canonical pathway hubs.la/Q032HMky0

Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans Journal of Experimental Medicine Quentin Riller neven benedicte doi.org/10.1084/jem.20…

Mutations disrupting the kinase domain of IKKα lead to #immunodeficiency and immune dysregulation in humans, say Quentin Riller (Quentin Riller), Frédéric Rieux-Laucat and colleagues Institut Imagine: hubs.la/Q032H50m0 #Autoimmunity #HumanDiseaseGenetics

Our Editorial : Improving Outcomes in VEXAS Syndrome: The Need for Prospective Data academic.oup.com/rheumatology/a…

.Quentin Riller et al. Institut Imagine present the first case of biallelic CHUK mutations disrupting IKKα kinase function, broadening non-canonical NF-κB defect understanding, and suggesting IKKα’s role in canonical NF-κB target gene expression in humans. hubs.la/Q032H94v0

A woman with multiply relapsed multiple myeloma had complete remission with cilta-cel, but a low-grade T-cell lymphoma soon developed in the GI tract that contained an insertion of the CAR construct disrupting expression of p53. Read the Brief Report: nej.md/40Yq3gO

.Quentin Riller et al. present the first case of biallelic CHUK mutations disrupting IKKα kinase function, broadening the understanding of non-canonical NF-κB defects hubs.la/Q03ggWjC0 📘 In Genes & Immunity collection: hubs.la/Q03ggWgF0 #HKS2025

In the absence of an HLA-identical donor, haploidentical HSCT with either TCRαβ/CD19 depletion or PTCY is a feasible option in CGD. ow.ly/t17w50VXkhp #transplantation #phagocytesgranulocytesandmyelopoiesis

Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome Congrats Paul Breillat Benjamin Terrier Kosmider olivier ashpublications.org/blood/article-…

Thrilled to share our latest research on impaired cytotoxic function and exhausted phenotype of NK cells in #VEXAS, with ⁦Paul Breillat⁩ Kosmider olivier and others, in ⁦Blood Journals Portfolio⁩, and supported by ⁦IMMUNOV⁩ ⁦Fondation pour la Recherche Médicale⁩ ashpublications.org/blood/article/…