Whoo hooo!! Congrats to Shicheng and members of Bryan Roth and @BShoichet labs for an amazing and thorough interrogation of the structure, function and pharmacology of 5-HT5A receptors! nature.com/articles/s4159…

Congrats!@ImmunologyTang

nature.com/articles/s4158…

😸 nature.com/articles/s4159…

Structural Genomics of the Human Dopamine Receptor System biorxiv.org/cgi/content/sh… #bioRxiv

Excited to share our new paper, out today in nature! We showed that a PVC (basically a 100nm molecular syringe) can be re-wired to deliver proteins into human cells. Thanks to my advisor, Feng Zhang, and my amazing co-authors at the Broad Institute nature.com/articles/s4158…

Merging art with AI. Using the new Outpainting capability,DALL-E 2 imagined how the landscape could look like between famous impressionist paintings from Van Gogh, Monet, Munch and Hokusai [source, read more: buff.ly/3F65vrL]

How do LINE family retrotransposons jump around? Can we reprogram retrotransposons? What does this have to do with Rum and Raisin? Answers here and below!

Finally--structures of D1, D2, D3, D4 and D5-dopamine receptors!! Congrats to folks from Bryan Roth , Eric Xu's lab and many others. nature.com/articles/s4142…

Broad researchers uncover new system in animals that can edit the human genome and may one day be developed into powerful new technology for genome editing. broad.io/Fanzors-news

Thrilled to share my first postdoc paper in ⁦nature⁩! We present a new RNA-guided system, Fanzor. Heartfelt thanks to ⁦Feng Zhang⁩ , Makoto, & team ⁦Broad Institute⁩, and cryo-EM facilities ⁦NYU Langone Health⁩ and ⁦MIT.nano⁩. nature.com/articles/s4158…

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s4158…

Excited to announce the opening of the Strecker lab at MGH Molecular Biology/CCIB and HMS Genetics. I am tremendously grateful to all of my labmates who have helped me over the years, my past mentors @durocher1 and Feng Zhang, and my new colleagues Dept. of Molecular Biology, MGH for the opportunity!

Now online! Flexible scaffold-based cheminformatics approach for polypharmacological drug design dlvr.it/T4lzYw

Excited to share that our latest work on Fanzor is now online in Cell ! By analyzing structures from different species, we’ve uncovered the structural diversity and how they cut DNA. Huge thanks to Feng Feng Zhang , Makoto, and all collaborators! cell.com/cell/fulltext/…