The Calculator includes automatic genetic ancestry similarity analysis using population reference panels. PGSs can be normalized across genetic ancestry similarity groups making it particularly useful for working on multiple biobanks to analyse diverse cohorts systematically.👇

The Calculator is portable: analysts can bring "code to the data" on any platform without transferring sensitive data. It supports offline environments and is scalable to population biobanks. Extensive documentation, a GitHub issue tracker, and a community forum support users. 👇

So far, the Calculator has been deployed to over 10 global biobanks, including HUNT, Genes & Health, China Kadoorie Biobank, and All of Us. Visit pgsc-calc.readthedocs.io to learn more and to install the calculator. AllofUsResearch @theHUNTstudy @GenesHealth

Now available in the PGS Catalog: pgscatalog.org/score/PGS00492… thanks to James Pirruccello et al for submitting! Submit your score pre or post-publication/preprinting, more info at pgscatalog.org/submit.

Last of the summer PGS, new metaPRS in our latest release: - For T2D, including many evaluations from Dr. Scott C. Ritchie @minouye271 et al pgscatalog.org/score/PGS00492… - New PGS for CAD, IS, ICH from China Kadoorie Biobank in Nature Human Behaviour pgscatalog.org/publication/PG… Stay tuned for fall 🍂!

📣 New updates to the PGS Catalog. These include multi-ancestry data and a new Calculator to simplify PGS calculations across different ancestries. Learn more about how these updates could enable more equitable disease risk predictions. ebi.ac.uk/about/news/tec…

Huge congratulations to everyone involved! @minouye271 Helen Parkinson Sam Lambert Ben Wingfield, Joel Gibson Laurent Gil Aoife McMahon Laura Harris NHGRI-EBI GWAS Catalog Health Data Research UK (HDR UK) BHF Cardiovascular Epidemiology Unit at Cambridge Baker Institute and more. Read the full Nature Genetics article here 👇 nature.com/articles/s4158…

📢 The Polygenic Score (PGS) Catalog has been updated, including data added from multi-ancestry or non-European populations and a PGS Catalog calculator. The project is a collaborative effort between Cambridge University, EMBL-EBI and NHGRI-EBI GWAS Catalog. Learn more: hubs.li/Q02Rdfc60

Check out the latest developments of all things PGS Catalog, out now in Nature Genetics (🔗: rdcu.be/dVakA )! In this paper we describe big increases in the data content (and diversity) and our tool for PGS calculation (github.com/PGScatalog/pgs…).

>5000 Polygenic scores now available at PGSCatalog.org! As of today's release we've broken 5k PGS, indexing data from 673 unique publications. A big thank you to the authors submitting their data and our team in pursuit of #openscience, #FAIRdata, and reproducibility!

Interested in software tools for calculating polygenic scores? Sam Lambert & @nebfield are giving an EMBL-EBI Training webinar December 4th about our pgsc_calc tool and it's capabilities for reproducible PGS calculation: ebi.ac.uk/training/event…! Join in or catch the recording after.

Polygenic scores can predict an individual’s genetic predisposition to certain traits or diseases. Join our #webinar learn how to use the PGS calculator for calculating polygenic scores. Registration is free but essential: ebi.ac.uk/training/event… #genomics EMBL-EBI PGS Catalog

Are you going to #FOG2025? Meet us to learn about the integration of processes with PGS Catalog or metadata generation and harmonisation pipelines for #SumStats. Share your data bit.ly/38rNSjx #openaccess

Our colleagues are at The Festival of Genomics & Biodata waiting for you! Come to the poster area to know more about latest updates at NHGRI-EBI GWAS Catalog and PGS Catalog #OpenAccess

📣 Thrilled to announce our collaborative tutorial with EMBL-EBI Training! Dive into the world of polygenic scores and explore the PGS Catalog resources (including pgsc_calc) - ideal for those seeking a comprehensive yet quick overview. Access it online at buff.ly/CEBWMio!

Discover data from our latest release: - New PGS for atrial fibrillation (pgscatalog.org/publication/PG…) - PGS optimised for East Asian ancestry in cancer (pgscatalog.org/publication/PG…) and 10 other common diseases (pgscatalog.org/publication/PG…) Submit data at pgscatalog.org/submit

Interested in calculating polygenic scores in the All Of Us workbench? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/how-…. Very much a work-in-progress, optimisations incoming!