Analysis of blood samples from patients with #LongCovid has revealed serum protein changes as the likely culprit. The results show potential biomarkers for diagnosis and could yield insights into treatment. scim.ag/5FX #SciencePerspective: scim.ag/5FW

A large-scale, whole-genome analysis in Science of over 12,000 cancers reveals previously unreported mutational signatures, including tumor-specific rare signatures. The findings may enhance personalized cancer treatments and diagnoses. #WorldCancerDay scim.ag/5KY

Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2 dlvr.it/T2PQ3f

Development of a Fluctuating Charge Model for Zinc-Containing Metalloproteins #Metalloproteins #MolecularDynamics pubs.acs.org/doi/10.1021/ac… #JCIM Vol64 Issue3 #compchem

Welcome Ramadan! 🌹 Welcome the Sultan of 11 months!🎉

New paper from #TeamAPOBEC: Allosteric APOBEC3B inhibitors! biorxiv.org/content/10.110…

It is my pleasure to announce the fruits of a great collaboration with people at SandboxAQ A diffusion model, end to end differentiable, optimizing many functions at once. In this example, we optimized binding affinity and synthetic accessibility. arxiv.org/abs/2405.11785.

This is another really nice general TPD review. nature.com/articles/s4158…

A mistake? No it wasn’t, he repeatedly said he’d attack Rafah and he did.

Today we report in Nature Biomedical Engineering the systematic application of six recent prime editing developments to enable efficient and functional correction of CFTR F508del, the predominant mutation that causes cystic fibrosis (CF), in primary airway cells from CF patients.

Very proud of this work, long time coming! The future is here.

In our new study out in Nature Communications, co-led by Xandra Nuqui and myself, in collab. w/ Jason McLellan & Kartik Chandran, we designed a 2W-stabilized SARS-CoV-2 S2 antigen exhibiting enhanced expression and preserved immunogenicity against sarbecoviruses. 👉 nature.com/articles/s4146…

No proposal or manuscript is ever perfect, but to be effective, it does eventually need to be finished. Nothing we submit will ever be as good as it *could* be and just recognizing that can be an important step forward. Perfection is not the goal. Finished is the goal.

New work on protein design... 🚨S2 immunogen design using advanced simulation WESTPA Software WE MD--> opening mechanism--> design--> stabilized protein--> cryoEM structure + immunology Xandra Nuqui Lorenzo Casalino Jason McLellan Kartik Chandran nature.com/articles/s4146…

Scientists discover that special immune cells stop metastatic cancer sciencedaily.com/releases/2024/…

Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.110…

The Baker Lab @UWProteinDesign recently hosted this powerful webinar on computational protein design. Take a journey through the history of this groundbreaking field, guided by some of the greats! youtube.com/live/BuJGTn7Oh…

The next Einstein, Curie, or Salk might be sitting in a lab right now, wondering if they should quit. Don’t let them. Fund science like the future depends on it…because actually it does.