The trial us CUP folks have been waiting for, CUPISCO! PFS better w/ molecularly-guided tx but the difference is modest, 6.1 vs. 4.4 mos but better in the subgroup w/ actionable alterations. Importantly, complex trials in rare cancers can be done, bravo! sciencedirect.com/science/articl…

It’s a good day in Minnesota… 😊

Selecting figs for a publication…

Can someone call me this kind of a doctor...? The NANETS abstract deadline is on Friday... If you have any exciting neuroendocrine stuff to report, please consider the annual NANETS symposium in Chicago in November. Disclosure: I am very biased towards NANETS... 😄

That’s pretty much spot on… Add to that 50-100 EMR messages, many very important and relevant, there isn’t much time left in the day to address emails so my apologies if I did not respond to your email. I probably never will…

Need some guidance on the management of high-grade gastroenteropancreatic neuroendocrine neoplasms (GEPNENs)...? We have you covered thanks to Amr Mohamed at University Hospitals in Cleveland Seidman Cancer Center and team incl. Bassam Sonbol 😀 erc.bioscientifica.com/view/journals/…

This is a very good piece... I doubt I got more than 60 min of lecturing on nutrition (not counting nutritional support like TPN...) during my entire training but that was a long time ago. Agree that large-scale prospective studies are needed. nature.com/articles/s4159…

FDG PET in CUPs... This study suggests that detection rate is overall 67% and that only 33% remain "true CUPs" after w/u. My experience is different, probably reflecting a different approach. FDG less useful and more CUPs remain CUPs Harry Fuentes MD MSc link.springer.com/article/10.100…

That was my view across the bay from Reykjavík tonight… Another day, another volcanic eruption I guess…

1 Hot off the press from team Memorial Sloan Kettering Cancer Center in Cancer Discovery! A study solving the puzzle of exceptional new lung cancer type: #Chromothripsis-mediated Small Cell Lung Cancer #SCLC This took nearly a decade and 42 coauthors to unravel. Here are some highlights 👇

How was your view last time you rode the bus to the airport…? I am willing to bet you didn’t see a volcano… Sorry, crappy pic from a moving bus…

Want to know more about alpha particle PRRT for NETs. Well, here is something for you to read... journals.lww.com/nuclearmed/ful…

The best title in the NET literature for the week: "May the Nuclear Medicine be with you!" Michael Hofman link.springer.com/article/10.100…

The first prospective evidence on neoadjuvant RLT for pancreatic NET is finally out on BJS .Great team work from eight Italian centers 🇮🇹 ENETS NANETS NET Cancer Day Neuroendocrine Cancer UK #NotJustNECancer Neuroendocrine Cancer NET CANCER FOUNDATION NETs México NET Research Foundation NETwerk NET- ESPAÑA

If you feel like reading about the genomic landscape of pancreatic NETs on this fine Friday morning, I have the paper for you by Dr's. Ana De Jesus-Acosta and Chirayu Mohindroo,MD. Great stuff! ascopubs.org/doi/full/10.12…

More on NGS and CUPs. CancerTYPE ID identified specific tumor type in 92.5% (all the usual caveats apply) and KRAS, IDH1/2, BRCA, and BRAF alterations were seen in 19% of which 25% had a potential option of getting an FDA-approved drug. NGS for all CUPs! ascopubs.org/doi/10.1200/PO…