Skin, Adult #Dermpath #Hemepath #BSTpath #Pathtwitter

An mbeimid ábalta caillteanas gnáthóige a stopadh agus cuidiú leis an nádúr teacht chuige féin arís? Beidh Darach Ó Murchú á fhiosrú anocht ar Cumhacht an Nádúir 21:30. Office of Public Works Pádraic Fogarty Irish Wildlife Trust Department of Housing, Local Government & Heritage Ecofact

1/3. Rare Dan Tweetorial or Renal: Kidney Biopsy in young man with metastatic disease. Looks nasty! CA9, P63 and GATA 3 negative.

RCC with fibromyomatous stroma ➡️Novel entity (PMID 33526874) 🔸Elongated branching tubules 🔸Abundant clear/pale cytoplasm 🔸Variable fibromuscular stroma - gives nodular appearance 🔹CK7 diffuse➕ 🔹CA-IX➕ 🔹CD10➕ Ass with mutations in TSC/MTOR and ELOC/TCEB1 #gupath

Angiomyolioma with epithelial cysts (AMLEC) 🔹Uncommon variant of AML ➡️HMB45/MelanA/Cathepsin K + 🔹Cystic component lined by cuboidal or hobnail epithelium (PAX8+) with subepithelial mullerian-like stroma (ER+) #gupath #pathresidents

PanIN-like vascular invasion is the most common type of VI seen in PDAC Tips to recognize - - Adjacent to thick walled vessel - Circumferential smooth muscle - Lonely gland in the peripheral fat Poor prognostic factor #pancpath #pancreas For more info; pubmed.ncbi.nlm.nih.gov/22082604/

34-year-old female patient with Graves' disease. No prior FNAC. Planned for thyroidectomy, but surgery was limited to the left lobe due to loss of nerve signals. 6 mm nodule evident during grossing. Encapsulated and well demarcated, macro- to microfollicular pattern:

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#GUpath: nephrectomy with classic "archipelago" (group of islands) pattern of renal oncocytoma #LPpath Dx at its best!

Hi @eflow_freeflow I have tried to contact you by phone and email for the past week and have received no reply to date. Can an agent please contact me?

The most common sarcoma in the hand, epithelioid sarcoma, can mimic GA or rheumatoid nodule. Best screening test is pan-keratin, as ES always is +. INI1 while helpful may be retained in up to 10% of cases. I never like doing a "negative test" for screening. #BSTpath Cleveland Clinic Pathology Residency

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In thyroid cancer, skeletal muscle invasion represents extrathyroidal spread, but this is only reliable in the lateral lobes and not the isthmus. This is due to Soemmerring's muscle arising from the hyoid bone and inserting on the isthmus. Be careful when assessing tumors here!

I have a post #immunotherapy complete response (yPT0) in a clear cell RCC on my desk. The advent of immunotherapy has changed the landscape of renal tumors & there are few things that give me greater joy than pushing the sign out button & imagining the patients relief. #Science

The exquisitely unusual invasive #urothelial carcinoma with prominent myxoid stroma (chordoid features) of the #bladder. It retains GATA3+ and p63+ and often presents with higher stage. Still not an official subtype as of 2022 WHO blue book. PMID: 19542871 #GUPath

Most monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) cases are CD8+; However, 10-20% can be CD8- like case below #Lymsm #GIpath #surgpath #PathTwitter #MedTwitter

RCPA is deeply saddened to hear of the passing of Nobel Laureate Professor John Robin Warren AC, an eminent and highly respected pathologist and medical pioneer. Professor Warren was the joint recipient of the 2005 Nobel Prize for Medicine alongside Professor Barry Marshall AC

Rare cases of FL/ DLBCL with BCL2 and IRF4 rearrangements exist, and should not be confused with large B-cell lymphoma with IRF4 rearrangement. FL/ DLBCL with BCL2 and IRF4 rearrangements typically show triple expression of CD10, BCL6 and MUM1 by IHC stains. FL/ DLBCL with

🔬🧬 Genetic Alterations in Salivary Gland Tumors 🧬🔬 For more details and MCQs: pathologymcq.com/genetic-altera…

As mentioned by many, this is Cystic trophoblastic tumour in a post chemo orchidectomy specimen. Degenerate remnants of choriocarcinoma after systemic chemo. hCG should only be mildly raised. As mentioned by Andres Martin Acosta (Andy): these tumours should be treated conservatively.