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Study demonstrates polycystin-2 is a key regulator of cardiomyocyte’s ability to produce natriuretic peptides in mouse and human models and that loss of cardiac-specific polycystin-2 in the absence of kidney involvement results in elevated diastolic and systolic BP

Now open! Incl an IgA nephropathy project in my group. We will fill in gaps in pathogenesis, aiming to better match new/upcoming drugs to each patient, and to find angles for next generation of treatments to remedy. Please get in touch if you want more info.

Quantifying the effect sizes across the spectrum of variants in cystic kidney disease is out today: shorturl.at/MkZFK Full thread discussing results below: x.com/OAlavijeh/stat… Great work again Omid S. Alavijeh, supported by Medical Research Council PKD Charity UK Genomics England #pkd #adpkd

We are heartbroken to announce that Prof (Stephen) Ben Walsh, died peacefully on 30th Sept while surrounded by family & friends. Both his family & UCL Renal are raising funds to find a way to honour his memory and achievements. More info below: justgiving.com/page/in-memory… Ben's

This comprehensive analysis of variants in cystic kidney disease leveraged 100,000 genomes! jci.org/articles/view/… @Oalavijeh Prof Danny Gale & team highlight the contributions to disease risk of different types of variants across the allelic spectrum.

Presented at #KidneyWk: This study showed that both monoallelic and biallelic APOL1 risk variants were associated with higher odds of chronic kidney disease and focal segmental glomerulosclerosis. Full study results: nej.md/48qtlM0

Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals. Browse scans at: mvp-ukbb.finngen.fi

📢The PKD Partnership—a collaboration between the PKD Charity and Kidney Research UK—seeks leaders for PKD research subgroups. This is a unique opportunity to shape the future of PKD research, make a meaningful impact, and improve the lives of those affected by polycystic kidney

#Medicine2050 From innovative dialysis solutions to xenotransplantation and AI-powered diagnostics, we explore the possibilities that could revolutionise kidney health in the decades to come ⏩ Melanie Chan @UCLRenal Rhys Evans Omid S. Alavijeh sciencedirect.com/science/articl…

Congratulations to Omid S. Alavijeh for a wonderful presentation and his Raine award #UKKW25!