What causes “thick walls” in the heart? 🔎 • Hypertrophy: Genetic (HCM), Hemodynamic (HTN, Aortic Stenosis), Endocrine, Athlete’s Heart • Infiltrative: Amyloidosis, Hemochromatosis • Storage Disorders: Fabry, Danon, Friedreich’s Ataxia #Amyloidosis #CVNuc ASNC Society

🔎 Key Echo Takeaways for #Amyloidosis: • Thick walls (>12 mm) + large atria + pericardial effusion = not always specific • “Starry sky” sign 🌌 isn’t specific—use GLS to quantify • Apical sparing with normal LVEF can be a major clue 🏆 #CVNuc ASNC Society

Takeaways on genetic testing for #Amyloidosis: • Common types: ATTRwt > AL > AA = LECT2 > hereditary • 15% of cases are hereditary 🧬 (watch for family history, younger onset, & TTR gene variants) • DPD/PYP can be positive in hereditary amyloid 🔎 #CVNuc ASNC Society

Sensitivity of Biopsies in AL #Amyloidosis 🎯 • Fat pad alone ~77% • Combine fat pad + bone marrow → ~89% sensitivity • Peripheral nerve, skin, liver, GI → 60~85% • Kidney & Heart → around 95%🌟 #CVNuc ASNC Society

Last day of Cardiac Amyloidosis Masterclass! Everything you need to know about treatment strategies Saurabh Malhotra Ahmad Masri and other distinguished faculty. Do NOT miss #ThinkAmyloid #CVCNuc - 🫶ASNC Society Panithaya Chareonthaitawee MD

Use of cardiac biomarkers for Cardiac Amyloidosis staging @Amyloiosisfdn BU Amyloidosis Center Mayo Amyloid Ahmad Masri Brett Sperry, MD Saurabh Malhotra International Cardio-Oncology Society ASNC Society #ThinkAmyloid #CvNuC

Excellent MASTERCLASS ON CARDIAC AMYLOIDOSIS from ASNC every year gets better - particularly exciting for our patients with new treatments on the horizon Important quality measures have to be in place THANK YOU ASNC Society Prem Soman Ahmad Masri Saurabh Malhotra Sarah Cuddy

Supply chain issues make it tough to rely on Tc-99m PYP for ATTR-CM, potentially delaying treatment. But did you know Tc-99m HMDP is a viable alternative? Join us next week to learn best practices for the use of each tracer & key differences. Register👉bit.ly/4hHf8xm

📢 Join us TONIGHT for the Optimizing the Diagnosis of ATTR-CM webinar! Learn the latest techniques for acquiring, interpreting & reporting Tc-99m HMDP & Tc-99m PYP—plus best practices for each tracer. Register👉bit.ly/4hHf8xm #cvnuc

Join us today for best practices for ATTR amyloidosis ASNC Society Saurabh Malhotra Panithaya Chareonthaitawee MD Ahmad Masri Sharmila Dorbala CIGDEM AKINCIOGLU 📷 tracers update and clinical cases🫀 #CVNuc #ThinkAmyloid

PYP test is a simple and transformative imaging for ATTR amyloidosis ASNC Society Saurabh Malhotra Amyloidosis #CvNuc ASNC Society SPECT imaging is needed to ensure myocardial uptake

Tips and tricks for ATTR SPECT imaging. 👇do not depend on planar -->Do SPECT 🫵 PYP uptake can be patchy or diffuse ✍️ Expect wash out with HMDP and scan at 1 hour ASNC Society #CVNuc Prem Soman Saurabh Malhotra

3 hour imaging with HMDP can lead to false negative scan for ATTR amyloidosis ASNC Society Saurabh Malhotra

🫀 Is it cardiac Amyloidosis? ASNC Society Prem Soman Saurabh Malhotra Ahmad Masri Sharmila Dorbala #CvNuc AMYLOIDOSIS ALLIANCE Amyloidosis Amyloidosis Research Consortium American College of Cardiology AHA Science

ATTR SPECT not always diffuse for Cardiac Amyloidosis. 👇👇👇 ASNC Society Saurabh Malhotra CIGDEM AKINCIOGLU Ahmad Masri #CvNuc

Kickstarting the American College of Cardiology weekend in Chicago with a packed house ASNC Society FIT Show-a-case. 30 cases, covering a wide breath of #CVNuc, being presented by FITs from all over the country and beyond. Panithaya Chareonthaitawee MD Prem Soman Karthik Ananth Richard L. Weinberg Mouaz Al-Mallah, M.D MSc

Presenting a case highlighting the importance of checking for incidental findings in nuclear #Hybrid_Imaging. At ASNC Society FIT Show-a-case Grateful to Mouaz Al-Mallah, M.D MSc for his invaluable mentorship. #CVNuc

Grateful my case was selected for the #ASNC FIT Case Competition! Huge thanks to my amazing mentors Marian VanDyck-Acquah MD FASNC FASE FACC Perry Wengrofsky, MD 🇮🇱 🎗️ for making this possible and ASNC for organizing such an enriching session for our educators! A great way to kick off the #ACC25 weekend! ASNC Society