Years ago Martin Rasmussen was on a Fulbright studying meningeal afferents in my lab & noticed dyes placed in CSF accumulate in trigeminal ganglia. This observation nucleated his PhD project in NedergaardLab & has now led to a new model of migraine pain. science.org/doi/10.1126/sc…

For millennia, migraine's origin puzzled scientists. We contributed to the Science Magazine paper showing how cortical spreading depression alters 11% of CSF proteome, including 2-fold increase in CGRP. The proteomic shift may explain aura-headache link. Nicolai J. Wewer Albrechtsen NedergaardLab

🏖️ Summer vacations are perfect for catching up on sleep! 💤 Discover why sleep is crucial for our brains through Maiken Nedergaard's pioneering work on the glymphatic system. Watch her fascinating #HFSPNakasone lecture: youtu.be/f7IcZag6loY #SleepScience NedergaardLab

A new Science study in mice identifies a novel non-synaptic signaling mechanism between the brain and peripheral sensory system important for migraine. Learn more ⬇️ 📄: scim.ag/7D5 #SciencePerspective: scim.ag/7D4

Really nice review discussing the anatomical and functional evidence for the SLYM layer. anatomypubs.onlinelibrary.wiley.com/doi/10.1002/ar…

Virally Induced CRISPR/Cas9-Based Knock-In of Fluorescent Albumin Allows Long-Term Visualization of Cerebral Circulation in Infant and Adult Mice link.springer.com/protocol/10.10…| Marta Vittani, Philip Aleksander Gade Knak, Masahiro Fukuda, Masaki Nagao, Xiaowen Wang, et al.

Online now! Cervical lymphatics drain CSF and clear metabolic waste from the brain. Du et al., show using 2P-OPTIC that these are disrupted in aging due to reduced pumping. Restoring cervical lymphatic function with PGF2a rescues brain clearance. doi.org/10.1038/s43587…

Beautiful paper from NedergaardLab in Nature Aging on the role of cervical lymphatics in cleansing of aged brain. Glymphatics/meningeal lymphatics = bff 🤩|| nature.com/articles/s4358…

#URochesterResearch via Nature Aging shows how scientists restored the brain’s ability to clear toxic waste in older mice with a drug that's currently used to induce labor. This points to a potential new treatment for #Alzheimers and #Parkinsons. Paper: go.nature.com/46WCR8F

New cool data on the impact of aging on cervical lymphatic vessels in Nature Aging – and how a prostaglandin can restore function. nature.com/articles/s4358…

Oxygen sensor for in vivo expression available now on Addgene: AAV vector expressing GFAP-GeNL addgene.org/221455/ NedergaardLab

Why sleep is important! biorxiv.org/content/10.110…

2 years of postdoctoral fellowship in Translational Neuroscience completed today. Grateful for the opportunity @UCPH_BRIDGE & Novo Nordisk Foundation. I thank my excellent mentors, Prof. Maiken Nedergaard & Prof. Messoud Ashina NedergaardLab Human Migraine Research Unit UCPH Healthscience #migraine

1/4 We are thrilled to announce that our 🌍 collaboration has resulted in a paper in JCBFM. @Gazz4_Science Catherine Foster Brad Sutherland University of Tasmania @SeattleChildrens University of Copenhagen doi.org/10.1177/027167…

How can understanding brain waste flow inform brain health? Prof Douglas Kelley, PhD, of Mechanical Engineering University of Rochester Hajim, aims to understand the glymphatic system so conditions like #Alzheimer's and #Parkinson's can be studied more effectively. #URochesterResearch In a Neuro

Reach out to us if you have further questions regarding the method. We are happy to help you!

12 Months of #Neuroscience March 2024 We can now see oxygen in the brain! It is already providing insight into why a sedentary lifestyle risk for diseases like #Alzheimers this #URochesterResearch method via NedergaardLab made the discovery using a protein similar to what gives

Out today in Cell ! We show that oscillations in norepinephrine and cerebral blood volume are the missing pieces that link NREM sleep to clearance of waste from the brain 🧠💤 cell.com/cell/fulltext/…

Vittani, Lee, Wang, Hiraoka, et al. KI mouse expressing red fluorescent blood In situ SpyTag/Catcher attachment of biosensor ECS SpyCatcher to capture BBB leak doi.org/10.1101/2025.0… We hope this method is useful to a wide range of the biology community.