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Nationwide US cohort 🏨 for newly diagnosed HFrEF n=33,036 >4 of 5 patients eligible for quadruple GDMT (>9 of 10 triple GDMT) <than 1 in 6 were prescribed it Substantial survival benefits being missed doi.org/10.1016/j.jchf… JACC Journals Steve Greene Duke Clinical Research Institute AHA Science

Steve Greene JACC Journals Duke Clinical Research Institute Harriette Van Spall, MD MPH Shahzeb Khan Clyde Yancy, MD, MSc AHA Science American College of Cardiology AHA Research Muthu Vaduganathan BiykemBozkurt Newly diagnosed HFrEF: extremely high risk 1-year ☠️ 36.3% Yet, some advocate to delay initiation of optimal quadruple GDMT for 6-12 months to see how patient “responds” to partial Rx Quad GDMT ✅ Rapid benefit ✅ ⬇️☠️by 68-75% ✅ Well tolerated alone/combo ✅ Cost-effective

Preventive stents for "vulnerable" plaque made a big splash at the #ACC2024 The PREVENT trial is an interesting and bold study. But. But. It's just a beginning. My thoughts are up on theheartorg | Medscape medscape.com/viewarticle/pr…

Really good point by Gary Mintz re PREVENT trial- does it make sense to do 803PCIs to prevent 12 cardiac events, of which only 5 were cardiac death / tv-mi #TCTAP2024 summitmd_cvrf Duk-Woo Park Hany Ragy Holger Thiele Ziad Ali David J. Cohen, MD, MSc Sukh Nijjer Erik Rafflenbeul Davide Capodanno

Cost effectiveness analysis of 💊 Rx in HFmrEF/HFpEF Timing of generic pricing is 🔑 Cost-Effectiveness of Medical Therapy for Heart Failure With Mildly Re... sciencedirect.com/science/articl… Boback Ziaeian 🤦🏻‍♂️ Neal Dixit, MD JACC Journals

💶💵 Cost-Effectiveness of Medical Therapy for HFmrEF/HFpEF 💊MRA 💊💊MRA + SGLT2i 💊💊💊 MRA + SGLT2i+ARNI ↗️ in life years of HFmrEF/HFpEF👥 💊1.04/0.99 2️⃣💊1.58/1.54 3️⃣💊1.80/1.77 💊MRA therapy ICERs of $10,000 per r QALY in both subgroups 💊💊ICER $113,000 per QALY in the

Once again, nice work Neal Dixit, MD . I often start SGLT2- and MRA first as easy to get to targeted dose fast. Now its cost effective too!

Should you wake up the patient when you preround? Not only is there a #kittlesonrules for that, there's also a piece in this week's NEJM. Check it out :) nejm.org/doi/full/10.10…

Generic priced options are here or just around the corner Cost-Effectiveness of Medical Therapy for Heart Failure With Mildly Reduced and Preserved Ejection Fraction | JACC: Heart Failure jacc.org/doi/10.1016/j.… Neal Dixit, MD JACC Journals

In #JACCHF JACC Journals: cost effectiveness of medical tx for #HFmrEF & #HFpEF *At current cost, MRA high value, SGLT2i intermediate value, & ARNI low value *If generic, all are high value 🛑Need equitable access to meds for all!🛑 jacc.org/doi/10.1016/j.… Gregg Fonarow MD Neal Dixit, MD

Cost-Effectiveness of GDMT for HFmrEF & HFpEF jacc.org/doi/10.1016/j.… JACC Journals #JACCHF Gregg Fonarow MD Boback Ziaeian 🤦🏻‍♂️ Muthu Vaduganathan Neal Dixit, MD Katie Truong, MD

Will DANCAVAS be the most important screening trial in the last 50 years? Interested to hear opinions! Read our commentary 👇🏾 sciencedirect.com/science/articl…

Costs? Intolerance? Inertia? Other? Primary reason for gaps in #GDMTworks endlessly debated. 🤔What if we had US physicians audit their own patient charts & report *WHY* they didn’t prescribe #GDMT for #HFrEF in each case? 🚨 Results in JACC Journals jacc.org/doi/epdf/10.10…

Is Finerenone just an expensive spironolactone? "A RCT of nonsteroidal versus steroidal MRAs is desperately needed in the HF population" Thanks for your thoughtful Editorial, Neal Dixit, MD and Saul Schaefer! Deutsche Gesellschaft für Nephrologie (DGfN) e.V. Young DGK marcus_saemann Swapnil Hiremath @hswapnil.medsky.social ahajournals.org/doi/10.1161/CI…

Ecstatic to share that I will be joining Howie Tran and the team at UC San Diego Cardiology Fellows for Advanced Heart Failure and Transplant Cardiology Fellowship!

Congrats Neal Dixit, MD !!! Can’t wait for you to join the awesome team at UC San Diego Cardiology ❤️

Is it primetime for finerenone in HF? Would love to hear why or why not? Here is our perspective 👇🏾 ahajournals.org/doi/10.1161/CI…

Is It Primetime for #Finerenone in #HeartFailure? ahajournals.org/doi/pdf/10.116… Circ: Heart Failure #MRA