Thrilled to announce our latest work in Cell! We've developed a new human neuron model that effectively mimics tau aggregate spread in tauopathy. Details here: cell.com/cell/fulltext/… (1/5)

Immunity Our paper on using the novel Clec7a-CreER mouse to label, track and manipulate PAM/DAM microglial states is finally out in Immunity Congrats to the first author Kia Barclay Kia Barclay Many thanks to the collaborators from The Colonna Lab Kipnis Lab Yu Lab @ Tsinghua Saligrama lab_WUSTL

I am excited to share our new study from the Blurton-Jones Lab "Therapeutic potential of human microglial transplantation in a chimeric model of CSF1R-related leukoencephalopathy" Neuron sciencedirect.com/science/articl…

We are  excited   to share new paper led by the talented Nicole Scott-Hewitt that a microglial C1q, can be  internalized by neurons in the healthy aging brain, undergoes liquid-liquid phase separation (LLPS), integrates into neuronal RNPs and impacts neuronal proteostasis 1/3

Out in Cell now with added data and analysis! Huixin and colleagues report that the choroid plexus has specialized epithelial-immune synergy that modulates epithelial barrier plasticity during brain inflammation. authors.elsevier.com/sd/article/S00…

Distinct vasculature topology renders microglia in the PVN more responsive to blood-borne signals, thereby microglia can transmit hemodynamic disturbance to sympathetic neurons. sciencedirect.com/science/articl…

Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells Nature Neuroscience nature.com/articles/s4159…

Can we use CRISPR screens to identify genes that drive neural stem cell aging? Super excited to see this work published nature! Huge congrats to Tyson @ruetz_tyson, Angie Pogson, Chloe Kashiwagi, and all authors! Great collaboration with Michael C Bassik! nature.com/articles/s4158…

Our latest study - psilocybin evokes structural neural plasticity, and we wanted to know how this maps onto pyramidal cell type-specific circuits to produce behavioral effects. 🍄🔬🧠 Link to bioRxiv: biorxiv.org/content/10.110… Led by Ling-Xiao Shao and Clara Liao.

Happy to share the lab’s latest research tagging psychedelic-activated neurons in mice. See the post below from first author Jessie Muir for a tweeprint on the work. Thanks to wonderful collaborators Olson Lab Lin Tian, PhD and to our reviewers/editor! science.org/doi/10.1126/sc…

Excited to announce that we are recruiting at our new Neurogenomics Center at Northwestern! We are looking for passionate postdoc candidates to join our team. nature.com/naturecareers/…

Are you using 5xFAD mice to study Alzheimer’s disease? Our work Neuron may be relevant to you 🐁 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. (1/11) cell.com/neuron/fulltex…

I am thrilled to share our latest article that has been published in Immunity. We describe a new role for NLRP3 outside of its inflammasome complex, where it can regulate microglial metabolism & key metabolites that affect the epigenetic landscape (1) cell.com/immunity/fullt…

Excited to share our new study in nature! We uncover how the vascular glycocalyx—a carbohydrate-rich coating on blood vessels—plays a crucial role in brain health and aging. A Tony Wyss-Coray & Carolyn Bertozzi labs collaboration. 🍭🧠 #glycotime (1/12) nature.com/articles/s4158…

Our new study! 🚀 With Doug Henze, we uncover region-specific adaptations in cerebellar microglia and provide detailed molecular and spatial data on age-related glial changes in the cerebellum. 🧠 #Microglia A Tony Wyss-Coray & Stephen Quake labs collaboration! biorxiv.org/content/10.110…

Another Tony Wyss-Coray & Stephen Quake labs collaboration! 🔬 With Doug Henze, we identify a subtype of disease-associated microglia with a ramified morphology, challenging conventional assumptions between cellular morphology and microglial states.🧠#Microglia biorxiv.org/content/10.110…

I am excited to present our new study out in Nature Medicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the Tony Wyss-Coray lab. 🧵1/12 Full study 🔗: nature.com/articles/s4159…

Thrilled to share that I’ll be launching my independent lab as a Rowland Fellow & PI Harvard University this Fall! Our lab will investigate how glycans (sugar molecules) modulate brain aging and neurodegeneration. We’re recruiting motivated scientists at all levels to join the team! 🍬🧠✨

My lab is recruiting a postdoc fellow to characterize new biochemical pathways that control taurine and glucose metabolism. Email me at [email protected] to apply! Please help RT🙏 Long Lab Judith Simcox PhD UW–Madison Biochem

We’re excited to share our recent study published in Cell! In this work, we show that brain endothelial cells, connected by gap junctions, form a signaling highway to enable fast, long-range arterial vasodilation in neurovascular coupling. cell.com/cell/fulltext/…