VENETOCLAX-HMA AS A BRIDGE TOWARDS HSCT OR DLI IN R/R AML library.ehaweb.org/eha/2024/eha20… #EHA24 #leusm

Autologous-allogeneic vs autologous tandem SCT w thalidomide for MM Pts: a prospective, phase II study
-PFS at 4 years after the second transplant was 47% (95% CI: 38-55%) for alloTSCT and 35% for autoTSCT! -No OS benefit
#mmsm #myeloma #MedEd #Medtiwitter #USMIRC USMIRC News

A retrospective registry study comparing the effect of fludarabine (Flu) doses suggests that high-dose Flu was associated with favorable outcomes in the Flu and busulfan group but not in the Flu with Melphalan group. ow.ly/ybkB50REM5l

Real-world data on diagnostics, treatment and outcomes of patients with hairy cell leukemia: The HCL-CLLEAR study
onlinelibrary.wiley.com/doi/full/10.10…

You don't know JAK(2) sh*t!

JAK2V617F =
95%PV
60% ET
60% MF

JAK2 exon12 = 2-5% PV

JAK2 rearrangements = Ph-like B-ALL

JAK2V617F+SF3B1 = RARS-T

PCM1-JAK2/BCR-JAK2/ETV6-JAK2 = Myeloid neoplasm ⬆️Eos

JAK2exon13InDel = PV+⬆️Eos

JAK2 46/1 haplotype = Familial risk for MPN

THROMBOCYTOPENIA (TP) WITH PARADOXICAL CLOTTING/VASCULAR OCCLUSION

TTP
HUS
DIC
PREECLAMPSIA/HELLP
OTHER TMA
HIT
APS
VTE CAUSING CONSUMPTIVE TP
SCD PAIN CRISIS

Others?

Inotuzumab ozogamicin for the treatment of adult acute lymphoblastic leukemia: past progress, current research and future directions jhoonline.biomedcentral.com/articles/10.11… #leusm

Atrial fibrillation a common complication of CAR T-cell therapy. Approx 10% in single institution study.
More common with CRS and higher levels of IL10, TNF & LDH and lower levels of fibrinogen.
#lymsm

onlinelibrary.wiley.com/doi/10.1111/bj…

Informative paper in Blood Journal re achievement of CRh with targeted therapies in AML!

ashpublications.org/blood/article/…

A study on clinical outcomes and toxicity in older adults (75+) receiving #CARTcell therapy underscores age alone is not a contradiction for CAR-T and found encouraging rates of overall survival across age categories. ow.ly/roq250RELZC

Transplant in AML: just follow the NPM1 guide!
ow.ly/lnLj50RARO5 #clinicaltrialsandobservations

Read our summary of a study published by Talha Badar comparing HMA + venetoclax with HMAs alone in adults with newly diagnosed TP53-mutated AML 👉 loom.ly/ZwBv1aM

#AMLsm #leusm #MedicalEducation

Improved outcome of allogeneic transplantation in older patients treated for myeloid malignancies using post transplantation cyclophosphamide and reduced duration of immune suppression Transplantation and Cellular Therapy Journal
astctjournal.org/article/S2666-…

Autologous hematopoietic cell transplantation consolidation for first response is associated with longer survival among patients with nodal peripheral T-cell lymphoma Transplantation and Cellular Therapy Journal
astctjournal.org/article/S2666-…

The role of pre-existing anti-HLA antibodies in severe aplastic anemia patients undergoing allogenic hematopoietic stem cell Transplantation and Cellular Therapy Journal
astctjournal.org/article/S2666-…

Combination therapy with novel agents for acute myeloid leukaemia: Insights into treatment of a heterogenous disease |British Journal of Haematology | Wiley Online Library onlinelibrary.wiley.com/doi/full/10.11… #AML #leusm

Ponatinib-review of historical development, current status, and future research AmericanJournalofHematology
onlinelibrary.wiley.com/doi/abs/10.100…

How I manage iron overload in the hemopoietic cell transplantation setting Blood Journal
ashpublications.org/blood/article/…

How I Treat Challenging Transfusion Cases in Sickle Cell Disease Blood Journal
ashpublications.org/blood/article/…

Honored to be co-senior author on this effort led by Dr Della Porta combining GenoMed and Moffitt database. Moffitt Cancer Center Clinical and Genomic-Based Decision Support System to Define the Optimal Timing of AHSCT in Pts With MDS | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…