Patching my first astrocyte with Ruilong Hu!

This is so cool!!! More evidence for the complex effects of Amyloid β and Tau on microglia. Plus more insight into the many Siglec receptors that are expressed by microglia throughout Alzheimer's progression!

Trash talk: Putting a stop to the garbage collection. #Microglia collect and dispose of garbage in the central nervous system. See all the images in the Cell Picture Show: 2021 KI Image Awards. Koch Institute at MIT hubs.li/H0_n2Hz0

Are you an undergrad hoping to spend the summer doing bio research at MIT? Consider applying to our 10-week MIT Summer Research Program in Biology (MSRP-Bio) before 1/30/22! See our website for application and program details: bit.ly/3oBH76r MandanaMSRP MIT Brain and Cognitive Sciences

The Stevens lab is hiring! Come work with an awesome group of scientists and be involved in cutting edge biology!

Closing out the year with an unpublished journal cover art image from our Alzheimer's (phospho)proteomics analysis: nature.com/articles/s4358… I'm looking forward to sharing the science in the pipeline for 2022!

Happy New Year ! Special thanks to my amazing lab -for their many contributions, generosity, hard work, creativity and resilience during this difficult year.Look forward to celebrating in person again soon over a nice cold glass of Microgliale -Stevens lab signature home brew

Wow! 30 years after Braak identified regions impacted at the earliest stages of Alzheimer's, Sabrina and colleagues have identified a genetic factor that can mediate this regional vulnerability. Incredible! cell.com/cell-reports/f…

biorxiv.org/content/10.110… Wow!! This is really amazing. This looks like a single molecule protein sequencer that is actually going to work! (And remarkably similar to journals.plos.org/plosone/articl…, with Adam Marblestone)

sciencedirect.com/science/articl… Excited to share Stevens lab first collaborative paper with Scott Small that shows neuronal retromer vps35 not only regulates neuronal phenotypes but also Microglia phenotypes in AD mode More to come on single cell( Samuel Marsh, Ph.D. ) function and signals..

Three views of a nucleus Cyan: total protein Magenta: nuclear localization domains Yellow: double-stranded DNA

One more day til… Glia in Health & Disease | CSHL My GLIA are Fired up for this! Can’t wait to see everyone at long last. meetings.cshl.edu/meetings.aspx?…

I am thankful to receive The National Institute on Aging (NIA) F32 award to develop new proteomics tools to study the molecular mechanisms underlying neurodegeneration. Would not have been possible without all the support from beth stevens and my graduate advisors, Forest and @DrLiHueiTsai!

are you at Alzheimer's Association #AAIC & looking for a postdoc in human neuro-proteomics? Come work with us on CSF proteomics of APOE4, in collaboration with beth stevens & Henrik Zetterberg (not on twitter)& colleagues at the new NIH-funded Duke-UNC ADRC- see neurojobs.sfn.org/job/33775/rese…

I'm excited to share our new cell surface N-terminomics technology to shed light on extracellular proteolysis ACS Central Science (pubs.acs.org/doi/10.1021/ac…)! Using #glycotime, @k_r_schaefer developed a glycan-tethered peptide ligase to capture proteolytic sites on living cells.

nature.com/articles/s4159…

I'm excited to share 2 of our new studies now out as preprints on BioRxiv! biorxiv.org/content/10.110… biorxiv.org/content/10.110… From Tony Wyss-Coray lab in collaboration with many amazing groups including... 1/5