81 y.o. M, cystectomy specimen. What is your diagnosis? #PathTwitter Mass General Brigham Pathology MGH Pathology

Differential diagnosis of carcinoma with squamous differentiation in the Thyroid Gland -Not every squamous cell carcinoma in the thyroid is anaplastic carcinoma Dr. Wiswanathan #USCAP25 #PathX #pathology

Thx Dan! Yes! So important to distinguish for appropriate patient care! ‘Shoulder’ of PUC is NCCN intermediate risk vs high risk for UCIS. It matters! 🔬

!! Extremely rare pitfall : Pseudo DCIS ("DCIS-like") invasive growth pattern seen in an invasive breast carcinoma, NST (invasive ductal carcinoma), grade 2. * last pic shows associated low-grade cribriform DCIS for comparison ** bonus in comments #breastpath #PathX

Thyroid vs parathyroid on frozen section?? Just flip that condenser and look for CALCIUM OXALATE crystals! - seen in colloid - can help make this distinction when present. #pathX #frozensection #pathology ❄️

Case of the day : M, 68, thigh mass with a nasty rhabdoid morphology. In waiting for the IHC results, first differentials would include melanoma with rhabdomyosarcomatous differentiation or an anaplastic/pleomorphic rhabdomyosarcoma. Opinions? #softtissue #Path #PathX

Retroperitoneal nodule. Can you nail this one? 🔨🔎 Poll below 🗳️👇 #PathPuzzle 🕵️‍♂️ Michigan Pathology #Pathology #PathX #PathTwitter

What’s this lesion of the breast? 🔬 Poll in the comments 👇 Answer to be posted on Monday #PathX #PathTwitter #breastpath #histology #PathQuiz

🚨 Coming up next after our fantastic session this week: We’re teaming up with pathCast for a free, open-access educational event on #gastriccancer – a comprehensive review you won’t want to miss! #GIpath 📅 August 16 📣 Open to everyone, not just GIPS members. Join us!

while you're better off using a "lymphatic specific" #IHCPath marker if you need to sort out lymphatic vs vascular invasion, often with CD31 the fainter staining pattern is seen in LYMPHATIC invasion ✔️here, #GUpath TURBT with LVI (likely "lymphatic" invasion)

Colleagues: the ISUP International Society of Urological Pathology website has been down recently while a new website was being built. New website is now available isupweb.net and in progress being expanded with additional features! An email to members was sent July 18 via mailchimp

#GUpath nephrectomy for single 4cm renal mass from adult, no priors #LPpath Dx (or Dx'es😉) ❓🔬

Answer time: Heterotopic hepatic tissue in the placenta and the stain shown in the image is HepPar-1! This is a rare finding😎 #PathX #PathTwitter #PediPath #GYNPath

#GUpath grading of multinucleate tumor cells in RCC is a bit controversial - some apply WHO/ISUP and render grade 4, others grade 3/descriptive ✅some data but more needed! 🔬to me these are different than "syncytial-type" multinucleate giant cells which I consider bad/grade 4

69 F with 3 cm kidney mass: Mixed epithelial and stromal tumor: Cysts lined by cuboidal cells, sclerotic stroma, ovarian stroma, adipose tissue in cyst wall

Pathologists-in-Training: View free resources in genomics education. Modules are available for undergraduate students, residents, and fellows via the Training Residents in Genomics (TRIG) website. uscap.org/path-in-traini… #PathX #PathTwitter

Buccal mucosa white patch. This is severe dysplasia p16+ with transcriptionally active HR-HPV. In contrast to the counterpart in oropharynx implications of HPV+ in oral cavity neoplasia is less clear and management is not currently altered by this finding #ENTpath #PathTwitter

Case of Pleomorphic Pattern 🔬 This rare pattern of invasive ductal carcinoma demonstrates pleomorphic and bizarre tumor giant cells and may represent the extreme end of “dedifferentiated” breast carcinoma or perhaps even metaplastic carcinoma. #PathX #PathTwitter #breastpath

Frontiers of Gastrointestinal & Hepatobiliary Pathology 2025 ✨💫In-person & Virtual 💻 Sept 27-29th This year’s Harvey Goldman Memorial Lecture will be give by Dr. Rish Pai “Diagnostic Approach to Colonic Polyps”. Don’t miss out- register today! learn.hms.harvard.edu/programs/front…

📣 Calling all #GynaePathology trainees! Join us for a Virtual Trainee Course 🗓️ 29 Sept 2025 🕐 Half-day PM 💻 Zoom | 🎟️ Free to attend 🔗 Register now: us02web.zoom.us/webinar/regist… #PathTwitter #GynaePath #MedEd