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Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice dlvr.it/TKk22q

I am pleased to share our recent publication, fruit of a wonderful collaboration with amazing colleagues Adrienne Boire and Jan Remsik, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> nature.com/articles/s4158…

Online now: Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease dlvr.it/TKmDWP

New content online: Fibroblasts in immune responses, inflammatory diseases and therapeutic implications bit.ly/3SB09dX

Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection Journal of Experimental Medicine Joseph Sun Lab rupress.org/jem/article/22…

A Perspective on a dynamic and multimodal framework to define microglial states from Roman Sankowski & Marco Prinz nature.com/articles/s4159…

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease nature.com/articles/s4146… Nature Communications A. Phillip West Jordyn VanPortfliet

Drs. Oleg Butovsky and Neta Rosenzweig published the article, “Alzheimer’s disease and age-related macular degeneration: Shared and distinct immune mechanisms.” Immunity cell.com/immunity/abstr…

Many congratulations to the new class of BWF PATH investigators. Extra kudos to the superlative Megan Orzalli, whose work continues to redefine our understanding of host defense. Megan Orzalli UMass Chan Medical School bwfund.org/news/announcin…

NLRP3 inflammasomes can assemble on most organelles. A beautiful study by Hafner et al demonstrate the flexibility of organelles that can support inflammasome activation. Kudos to the authors on an intriguing study. nature.com/articles/s4146… Iva Hafner Bratkovic Elvira Boršić

Astrocyte morphogenesis requires self-recognition nature.com/articles/s4158… nature Alina P. Sergeeva

These students are earning a dual degree from UMass Chan Medical School today. Say hello to our physician-scientists: the MD/PhD students in the Class of 2025! 🎓 #UMassChan2025 #ClassPhoto #MDPhD #MDPhDLife #MedEd #MedTwitter #PhDTwitter #UMass UMass Chan MD/PhD Program University of Massachusetts Zach Dyer

Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain: Neuron cell.com/neuron/fulltex…

Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory science.org/doi/10.1126/sc… Yannick Alexandre Science Advances Scott Mueller

Gilles E. Martin identifies a group of 500 neurons associated with the suppression of binge drinking Nature Neuroscience: brnw.ch/21wTj0s

Have you registered yet for #ReThinkNeuroimmunology in October? Organizers, Fran Quintana Lab @Stevens1Lab @JonyKipnis IdoAmitLab Rejane Rua have put together stellar program for the 3-day event. #RTN ⁩ Register here:🔗genelayinstitute.org/rtn/

ILC3s are a RORγt+ APC that sense the microbiota through STING to induce microbiota-specific Treg cells cell.com/immunity/fullt… Immunity

Neuroinflammation across neurological diseases Science Magazine science.org/doi/10.1126/sc…

Activation of macrophages engulfing neutrophils by TNF switches efferocytosis to caspase-8–mediated pyroptosis and IL-1β production Science Immunology Poltorak Lab science.org/doi/10.1126/sc…

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway: Immunity cell.com/immunity/fullt…