The enzymes for polyphosphate formation are present in nearly all bacteria, but only some store large amounts of polyP. Why? Arcadia Science we tackled this problem by looking at structural similarity of the protein catalyzing polyP formation 🧵 [1/12] research.arcadiascience.com/pub/result-ppk…

Come work with us!

New job alert: know someone who loves to scale and automate workflows in the lab? We want to apply new tools to onboard a diverse array of species in the lab! Spread the word 🙏 jobs.lever.co/arcadiascience…

🧊 Scientists know the importance of failing fast. We wear this like a badge of honor Arcadia Science w our published “icebox”. We recently got an update from the team to see how this experiment is going after 9 months. (1/5) 👉research.arcadiascience.com/pub/perspectiv…

We’re heading to #cellbio2023! Check out ascb2023.arcadiascience.com to see the posters we’re presenting and what else we’ll be up to. But keep reading — we want to hear from you! 👇 1/3

If you’re attending #CellBio2023, don’t forget to send your favorite proteins (submit on ascb2023.arcadiascience.com)! Then, come see me and @arcadiascience at booth #434 to check out an interactive structure-based map generated by ProteinCartographyand to chat about our other work!

In our new pub, we investigate disease-associated repeat expansions (dREs). Expansion of DNA repeats can cause neurodegeneration, as in Huntington’s disease. We looked for dREs across the tree of life, and found them in surprising, and cute, places!🧵1/7 arcadia-research.pubpub.org/pub/result-neu…

🚨 An updated version (v0.4.2) of the #ProteinCartography pipeline (our tool for protein comparisons across species) is now available: github.com/Arcadia-Scienc…

How might structural differences within the actin family lead to insights about its proteins’ functions? I’m excited to share how we Arcadia Science evaluated the #ProteinCartography pipeline and generated new hypotheses about the actin family! 🧵[1/4] research.arcadiascience.com/pub/result-act…

Can we identify more human-relevant and research-friendly models by unifying various genetic approaches? Join us at #TAGC24 to hear about our approach to integrating genetics and comparative methods to predict drivers of biological innovation! tagc2024.arcadiascience.com

At Arcadia Science we also share our negative results. Dive into our latest work where we employed trait mapping and evolutionary analysis in search of the function of a structurally divergent actin isoform in fungi. Discover more in our thread 🧵 [1/8] research.arcadiascience.com/pub/negative-d…

I’m at #TAGC24 to talk about ProteinCartography! Stop by and check out our website for our other events

If you’re a fan of DIY lab equipment, you’ll love the phenotype-o-mat, a customizable DIY 96-well plate imager from Arcadia Science that you can now build for only $400 🧵 1/7 protocols.io/view/building-…

Join the discussion of our latest review at alphaXiv. Check out the great comment (by Dennis Sun (孙丹) / Arcadia Science) — and our response — about the extension of these computational strategies to non-traditional #ModelOrganisms.

Srinivasan has posted responses to our manuscript documenting data duplication in his papers. They are filled with insults, and all instances of identical data are dismissed as "typographical errors." You can find his responses and our thoughts here: github.com/pachterlab/LP_… 🧵

Happy Darwin Day! Today we’re thinking about how to use evolution to accelerate biomedical research. We think the answer is to expand the repertoire of organismal models. Search for the best ones using our new portal Zoogle: zoogle.arcadiascience.com/about 🧵