We present The Transcription Factor Binding Landscape of Mouse Development🐭🧬 #DevBio We use CUT&RUN-LoV-U to map Many SignalingPathways X 4tissue X 2stages It is a huge dataset - yet only the beginning of the TranscriptionFactorBinding(TFB)-OMICS biorxiv.org/content/10.110…

G1 length dictates H3K27me3 landscapes biorxiv.org/content/10.110…

Checkout the latest work from the lab online today in Molecular Cell where we find that distinct sequence features encoded in IDRs are responsible for targeting proteins to specific condensates. This work was led by Nancy De La Cruz Prashant Pradhan and Reshma T Veettil .

The final version of is now published: nature.com/articles/s4146… Congratulations Matvei Khoroshkin and our team across 3 groups, ours, Faraz K Mardakheh, and Vanja (Ivan Kulakovskiy)!

Our work on pooled protein recruitment is finally out Cell Genomics! cell.com/cell-genomics/…

I've now compiled "30 Great Essays About Biology" into one article. Hopefully this will be a useful resource for students and others hoping to learn more about this field. Enjoy!

Excited to share our latest work developing DART transgenic mice and using them to profile m6A in single cells of the mouse brain. A fantastic study led by Matt Tegowski with contributions from Holley Lab nature.com/articles/s4159…

Our latest paper is out! In collaboration with Anne Carpenter, PhD, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/…

Beyond thrilled to present our O-MAP—now *published* Nature Methods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 nature.com/articles/s4159…

Excited to share that the AlphaFold 3 model code and weights are now available for academic use. Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmin… 1/2

Join me at 🦋 Christine Mayr.bsky.social

How do cells transit from fate to fate? Quietly. MIT ChemE Dept

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration: biorxiv.org/content/10.110…

1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! 🧵👇 nature.com/articles/s4158…

Site-saturation mutagenesis of 500 human protein domains: nature.com/articles/s4158…

Rapid and scalable personalized ASO screening in patient-derived organoids: nature.com/articles/s4158…

Join us on April 24 for the #HIRM #RNA Medicine 10th Annual Symposium feat. One of our speakers Christine Mayr from Memorial Sloan Kettering Cancer Center Register now: lp.constantcontactpages.com/ev/reg/yy37udr… #HiRM BIDMC Cancer Center

Wow! Amazing finding

More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…

Excited to share our preprint on 3'UTR-chaperoned IDR functions!Check it out if you work on a protein with a long IDR and a highly conserved 3'UTR in the mRNA!