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So stoked to be sharing this! New proteomics map of human subcellular architecture. CRISPR + organelle IP mass spec at scale. Check out pre-print biorxiv.org/content/10.110… and organelles.czbiohub.org. 🙌 to fantastic team Chan Zuckerberg Biohub Network SF & collabs! 1/2

Thrilled to see Mantis🦐🔬 💻, our new platform for high-throughput imaging and analysis of cell dynamics, in the wild. I am proud of and thankful to the team Chan Zuckerberg Biohub Network and Bo Huang Lab 🙌.

This is a pretty cool idea for signal amplification in fluorescence imaging: first fuse the target protein with a biotin ligase, then label with a fluorescent streptavidin:

A #GPCR milestone from M. Madan Babu & Franziska Heydenreich, with Kobilka @stanford Michel Bouvier. Integrating pharmacological and structural data on beta2AR reveals the allosteric network that translates and decodes adrenaline binding into signaling response. science.org/doi/10.1126/sc…

Happy holidays and a good resolution for 2024 🔬😀!

Looking forward to Biophysical Society BPS2024 meeting in 1 month!

The authors “advocate for the value of learning and surprise, and for an irreverence for boundaries of all kind — between disciplines, science and technology” This was the Bell Labs culture and became the guiding light for my own research! nature.com/articles/s4225…

Very exciting to be at the BPS Biophysical Society meeting is Philadelphia! The talks yesterday were wonderful. Looking forward to today!

Excited to give my talk about cathodophores for multicolor EM in 1 hr! Not sure who "Xiaowen Zhuang" is but they seem to be doing cool work... 🤷‍♂️

Thrilled to join the CZI neuroscience community together with Joongkyu Park ! Grateful for the support from Chan Zuckerberg Initiative for our team efforts to uncover the roles of brain lipid droplets!

Interdisciplinary and Inter-Institutional Partnership Studying Neurodegenerative Diseases Wins Support from Chan Zuckerberg Initiative Jeeyun Chung Chan Zuckerberg Initiative CZI Science Harvard University Joongkyu Park Rachelle Gaudet mcb.harvard.edu/department/new…

New and improved way to generate difference maps, from my neighbors in the Hekstra Lab ! Give it a try. :)

We updated our database of POSTDOC fellowships. We identified 316 different fellowships. For each entry, we provide a link to the funder, amount, deadline, and eligibility criteria. Download this free database here: research.jhu.edu/rdt/funding-op…

Great talk today at MCB_Harvard by Elçin Ünal from UC Berkeley MCB about aging and rejuvenation of gametes in meiosis. The slide on the photo highlights the efforts of Elçin's former PhD student Jay Goodman, who was an UG student working with me at Chemistry at Illinois. Small world 🙂

It cannot be done, they said.. It's too flexible, they said.. 😁 biorxiv.org/content/10.110… #NPC #teamtomo #integrativemodeling by Digvijay Singh Neelesh Soni Josh Hutchings Ignacia Echeverria et al. Great collaboration w/ Qiang Guo, Brian Chait, Javi Fernandez-Mtnz, Rout Lab Andrej Sali lab

I’m super excited about the visit of my role model, Pietro! Not only have his contributions advanced our understanding of neuronal membrane biology, but he is also a wonderful mentor. His guidance has shaped the mentor I aspire to be for my trainees. 😊De Camilli Lab Yale Cell Biology

Inaugural Alma Dal Co Alma Dal Co lecture delivered today by Uri Alon. This is the first time I saw a seminar speaker give a chalk talk. It actually worked pretty well. Would you try it?

We have an openning for a postdoctoral fellow interested in pursuing method development in cryo-vitrification (cryo-plunging and high-pressure freezing) for applications in studying nanoscale cellular organization using super-res imaging and cryo-ET. DM or e-mail me. Plz RT! 🔬🧊

A New Window into Protein Interactions at the Nanoscale Max Prigozhin Sohaib Abdul Rehman PNASNews Harvard SEAS Jeremy B. Conway Harvard Griffin GSAS Rachelle Gaudet Harvard University mcb.harvard.edu/department/new…