Transcription-associated DNA breaks and cancer: A matter of DNA topology dlvr.it/S7N5TD

Interested in applying CRISPR screening technologies to discover new DNA repair genes and functions? In our latest review written by Sam Hayward we discuss the use of CRISPR screens for the study of homologous recombination! @ELS_Genetics authors.elsevier.com/a/1dor2,LqAZQA…

DNA ligase III loss induces MRE11-mediated ssDNA gaps and PARPi sensitivity in BRCA1−/−53BP1−/− cells Molecular Cell cell.com/molecular-cell…

Glad that our review on "Targeting small GTPases and their downstream pathways with intracellular macromolecule binders to define alternative therapeutic strategies in cancer" is now out Portland Press. Written with Marie Sorbara. CRCT-Oncopole Biochemical Society portlandpress.com/biochemsoctran…

Very happy to share our work investigating the role of RNase H2 in maintaining R-loop balance and preventing DNA breaks in human cells Nature Communications! Thanks to GromakLab Dunn_School (now @DunnSchool.bsky.social) and all co-authors Michael Tellier Nicolas Bery and the others nature.com/articles/s4146…

L'association alk ros1 france cancer poumon fait un don de 5000 euros à la recherche à l'équipe SIGNATHER du CRCT-Oncopole de Toulouse. crct-inserm.fr/un-don-pour-la…

#ConferenceduCRCT | Vendredi 13 janvier à 11h00 Le Dr Sarah Lambert de l'Institut Curie interviendra au CRCT sur : "Building a barrier to replication fork degradation with Okazaki fragment". #Cancer Plus d'infos 👉bit.ly/3QroiSq

Sunny all-day retreat of the Favre/Sordet team CRCT-Oncopole team in Toulouse countryside. Exciting projects regarding biomarkers, liquid biopsies, transcription R-loops, Double-strand breaks, resistance to targeted therapies and translational research. Great team to defeat #LungCancer

Le CRCT-Oncopole recrute un(e) Ingénieur(e) en #Bioinformatique. CDD 24 mois temps plein Prise de fonction à partir du 01 septembre 2023 Consulter l'annonce ➡️crct-inserm.fr/recrutement/

TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks dlvr.it/T71zmm

embopress.org/doi/full/10.10… Excited to share our latest publication in EMBO Journal on TDP1 phosphorylation at S61 in mitosis and genome instability and Cancer. Congratulations Srijita!! for her incredible PhD work. DSTIndia SERB Department of Biotechnology ICMR Indian Association for the Cultivation of Science

Check out this #protocol by Mathéa Geraud Agnese Cristini Lara Fernandez andrea carla ajello Favre/Sordet team et al for single-cell analysis of DNA double-strand break production and repair in cell-cycle phases by automated high-content microscopy: star-protocols.cell.com/protocols/4059. 🔬🧬Research in