Check out Miriam Hood's poster this afternoon from 1:45-3:45PM at #BPS2023 - INVESTIGATING DIFFERENCES BETWEEN THERMODYNAMICALLY AND KINETICALLY STABLE SUBTILISINS TO IDENTIFY SEQUENCE SIGNATURES OF KINETIC STABILITY l.core-apps.com/bpsam2023/even…

Check out UPAC finalist Megan's poster this afternoon from 1:45-3:45PM at #BPS2023 - EPITOPE MAPPING OF DIAGNOSTIC ANTI-RABIES MONOCLONAL ANTIBODIES PROVIDE STRUCTURAL INSIGHT INTO RABIES VARIANT IDENTIFICATION IN INFECTED WILDLIFE l.core-apps.com/bpsam2023/even…

happy to finally share our published (!) paper on how changes in conformational flexibility drive the function of a paradigm transcription factor, the lac repressor: rdcu.be/c6GJo

Congratulations to Susan Marqusee !!! 🎉🎉🎉

We happy to finally share the published version of our manuscript on a highly conserved SARS-CoV-2 epitope at the apex of the S2 domain! Press release: news.utexas.edu/2023/03/21/the… TexasChE Texas Engineering NaturalSciences @ UT

Our paper characterizing the mechanism of allosteric modulation of the glucagon receptor by RAMP2 is out Cell! Check out the link below for a free copy. authors.elsevier.com/c/1gqie_278y~T…

Secondary Structure Detection Through Direct Nanopore RNA Sequencing biorxiv.org/cgi/content/sh… #biorxiv_biophys

Using hydrogen-deuterium exchange, Glasgow Lab, Marqusee Lab, and Kortemme Lab propose a model explaining how a classic transcription factor undergoes changes in its conformational ensemble in response to different ligands. nature.com/articles/s4146…

Chemist Susan Marqusee takes leading role at National Science Foundation news.berkeley.edu/2023/05/16/che…

Congratulations to our grad student Darren Kahan on being awarded the AdvancedLightSource Doctoral Fellowship in Residence! He will be working with Dr. Corie Ralston’s lab at the Molecular Foundry

Happy to be a part of such a cool story! Structural & dynamic characterization of mGluR intermediate states. Congratulations to Kaavya, Haoqing Wang and all authors. Another productive collaboration with Isacoff Lab & Marqusee Lab!

It’s out! Via hydrogen deuterium exchange, biochemistry, and cryo-EM, we (Walter lab, Marqusee Lab et al) discovered the allosteric mechanism controlling activity of the core Integrated Stress Response (ISR) regulator eIF2B. 1/10 nature.com/articles/s4158…

.Natalie Dall's paper is up on bioRxiv! Using high-throughput in vivo studies and biophysical in vitro assays (CD and HDX/MS), we show how circular permutation affects the expression of HaloTag in different cell environments, and how CP impacts protein stability and folding pathways

Big congratulations to PhD student Thea K Schulze from our PRISM centre on being awarded the elite research travel grant by the Minister for Higher Education and Science, Christina Egelund, to support a stay in the Marqusee Lab at Berkeley to study protein variant effects 💪🧬💻

Super cool work by twitterless Naomi and crew looking at domain coupling in mGlu receptors. Marqusee Lab Isacoff Lab Domain coupling in activation of a family C GPCR biorxiv.org/content/10.110…