inPhase - A simple, accurate and fast approach to determine phase diagrams of protein condensates biorxiv.org/content/10.110…

Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.110…

The G3BP Stress-Granule Proteins Reinforce the Translation Program of the Integrated Stress Response biorxiv.org/content/10.110…

Happy to share our little discovery with Simone Mattei team on how ribosomes hibernate upside down on mitochondria during cellular stress is now out Nature Communications! A collaboration between @medicineUVA, @EMBL, EMBL Imaging Centre, MEMC. Congrats to all authors! nature.com/articles/s4146…

Ribosomes hibernate on mitochondria during cellular stress: nature.com/articles/s4146…

New purifications reveal yeast and human stress granule cores are discrete particles with complex transcriptomes and proteomes doi.org/10.1101/2023.1…

Happy to share that our preprint on the regulation of NPC (a)symmetry is online! #teamtomo #NPC #phdlife Wouldn't have been possible without the support of the amazing Beck Laboratory and great collaborators outside Sven Klumpe, MandyBoermel, @WilflingFlorian!

Beyond thrilled to present our O-MAP—now *published* Nature Methods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 nature.com/articles/s4159…

Excited to share our latest work! We developed a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity methods, labels deposited on RNAs are read directly by sequencing without a need for biotinylation. biorxiv.org/cgi/content/sh…

“An RNA world, in which RNA took on the tasks of DNA and proteins, might have preceded the DNA-based life we know today.” Read about the multifaceted functions of RNA in this month’s newsletter: laskerfoundation.org/rnas-extreme-m…

Virus-modified paraspeckle-like condensates are hubs for viral RNA processing and their formation drives genomic instability: nature.com/articles/s4146…

Cells keep tabs on RNA production in the nucleus to control the levels of RNA degradation in the cytoplasm. elifesciences.org/digests/90766/…

inPhase - A simple, accurate and fast approach to determine phase diagrams of protein condensates doi.org/10.1101/2024.1…

G3BP1 promotes intermolecular RNA-RNA interactions during RNA condensation: cell.com/molecular-cell…

First paper of our lab today nature by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! EMBL doi.org/10.1038/s41586…

PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms. doi.org/10.1038/s41467…

Molecular determinants of condensate composition: Molecular Cell cell.com/molecular-cell…

Programming biological communication between distinct membraneless compartments: nature.com/articles/s4158…

Nuclear pores safeguard the integrity of the nuclear envelope: nature.com/articles/s4155…

Excited to share our preprint, now available online on BioRxiv! biorxiv.org/content/10.110…. We uncovered the coupling of translation and secretion machineries at the #axonalER to promote local delivery of axonal transmembrane proteins (TMPs) to the plasma membrane.